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Developments in Phosphiranium Ions Chemistry – DePhI
The main challenges are to develop reliable, effective and general phosphiranes and phosphiraniums synthesis methods, and then to tame their C-selective ring-opening reactions by the widest possible range of nucleophiles, in a streamlined and predictive manner. 1-Central to the DephI project is the
Chemoselective thiofunctionalization and 35S radiolabeling of peptides/proteins – Thio-Fun
Functionalizing therapeutic peptides or proteins would make it possible to discover new biological activities or new therapeutic targets. Important preliminary results were obtained on the mercapolization of halogenated aryls. The reaction takes place under mild conditions at Ta. The extension to pe
Ugi Reaction for the Site-Specific Bioconjugation of Native Proteins – BioconjUgi
The chemical modification of proteins - bioconjugation - is of major interest, particularly in the therapeutic field, thanks to the additional properties it can confer: better stability, use in targeted therapies, fluorescence, etc. The conjugation methods currently available focus on the use of ar
Rational design of chemosensory compounds targeting smell, taste and emotion – chemosim
ChEmoSim is a fundamental and highly multidisciplinary project. It gathers academic experts in computational modeling, protein engineering, neuroscience, and a company expert in sensory analysis. The research hypothesis is that numerical models can crack the code of chemosensory sensations. To achie
Redox modulation of rhodium-catalyzed nitrene insertions into C(sp3)-H bonds – CHamRhOx
The direct transformation of C-H bonds into C-N bonds is an area of intense research because, as an atom-economical reaction, it makes the synthesis of complex nitrogen-containing molecules more efficient, with multiple applications in both life sciences and fine chemistry. In this context, rhodium-
Peroxide-Free (Photo)Initiating Systems – NoPerox
Photopolymerization has witnessed intense research efforts related to the constant progression of industrial applications associated with the synthesis of new photopolymers and monomers. However, this technique is still limited to the polymerization of thin films. On the contrary, redox priming syst
Gold(III) chemistry – Gold-III
The unique properties of Au(III) complexes make them very appealing in catalysis but the rarity of stable yet reactive Au(III) complexes has so far limited the advent of Au(III) catalysis. This project aims at elaborating a library of well-defined Au(III) complexes and at opening a new facet in gold
Synthesis, Aromaticity and Reactivity in Distorted Polycyclic Aromatic Hydrocarbons – TWISTAR
3D curved nanocarbons are promising next-generation materials. The TWISTAR project aims at providing deep insights on the potential, limits and true nature of highly twisted large chiral polycyclic aromatic –or not– hydrocarbons. In accordance with the project's predictions, to date we have obtained
Switchable Mulfunctional Advanced Compounds – SMAC
SMAC is a multidisciplinary project in the field of nanoscience with the objective of designing, synthesizing and studying multifunctional compounds whose magnetic properties or luminescence can be modulated by an external stimulus. The switching effect involved in the present study is essentially b
Innovative Chiral Molecules for the Construction of Efficient Circularly Polarized Light Emitting Devices – iChiralight
The main objective of this multidisciplinary project is to design novel chiral TADF molecules (organic, organometallic) and incorporate them as emissive dopant in CP-OLED devices displaying high degrees of both electroluminescence polarization and efficiency. 1) First structure/property study for CP
ALL-OPTICAL FUNCTIONAL MOLECULAR MATERIALS – PhotoControl
The development of new functional molecular materials based on photo-active molecules is a high priority strategic research field in this century. Notably, those dedicated to data storage and processing attract increasable attention in academic and industrial research, driven by economic and energy
Exploration of the astatine-metal bond: design, synthesis and stability study – ExpAt
Astatine-211 is a promising radioisotope as a therapeutic tool due to the alpha particle emitted upon it radioactive decay. In order to use this property, it is necessary to bind it chemically to a carrier molecule able to transport it to the diseased cells to eradicate. Alpha particles being highly
Remote functionalization of molecules with supramolecular catalysis – REMOTCAT
Pyridines are key molecules in biology and materials science. Unfortunately, they are highly difficult to functionalize by means of transition metal (TM) catalysts as they displace the ligands of the metal active center via coordination of the nitrogen lone pair. This inhibits the catalysis or, at
Cell wall “clicking” as a selective weapon against Streptococcus pneumoniae – PneumoClick
Creating chemical bonds in a controlled manner in a living cell has a great potential of applications in the fields of biology and medicine but remains a major challenge. In the PneumoClick project, we will exploit click chemistry and specificities of the cell wall biosynthesis pathway in the human
Dynamic assembly of aromatic oligoamide foldamers for stabilizing protein-protein interactions – FOLDynamic
Protein-protein interactions (PPIs) play crucial roles in many biological processes and diseases, and represent potential targets to develop new therapeutic approaches. With their medium size, stable conformation and proteinogenic side chains, synthetic aromatic oligoamide foldamers may be valid can
Cooperative Catalysis Between Metal Single Atoms and Nanoparticles – COMET
Supported metal catalysts dominate the production technology of chemicals, fuels and polymers, and help protect the environment. Since the active phases are often composed of noble metals, expensive and for the most part identified as critical elements, a logical step is to optimize their dispersion
Electrochemically promoted tyrosine-click-chemistry for protein labelling – E-CLICK
Bioorthogonal ligation methods are extensively explored for the development of protein conjugates, which are of considerable importance in the therapeutic field and in biotechnology industries. The electrochemically promoted tyrosine-click-chemistry for protein labelling (e-CLICK) project will consi
Strong and Tunable Zinc(II) Cationic Lewis acids: synthesis and use in selective Catalysis – Tu-Zin-Cat
The fundamental reactivity of Zinc cations will be studied and exploited for catalytic reactions of current interest, including their use for the selective transformation of biomass substrates (carbohydrates and sorbitol) to added value products and for the hydro-elementation (hydro-boration/-silati
Organolanthanide complexes with slow magnetic relaxation – RelaxMax
The objective of the project is to make high-performance molecular magnets from organometallic compounds of lanthanides. In particular, we are interested in compounds of the sandwich type with the broad ligands of the cyclooctatrienyl (C8H8, Cot) and cyclononatetraenyl (C9H9, Cnt) type. The original
Enantioselective Organocatalysis through Hydrogen Bond-Assisted Halogen (X) Bonding – Bond-X-Bond
The goal of the project is to develop new organocatalysts that function by halogen bonding, a stabilizing interaction that is established between halogen atoms attached to an electron withdrawing group and Lewis bases. The halogen bond has been applied to organocatalysis reactions for about ten year
Confined Lewis Acid/Base – Co-LAB
The objective of this project is (i) to activate small gas molecules and (ii) to perform multiple catalysis (double cooperative catalysis, relay catalysis), using different catalytic sites isolated thanks to their endohedral confinement in covalent cages. New cages with a confined Lewis base could b
Hock and interrupted Hock reactions: mechanisms, reaction design and synthetic applications – RHOCKI
RHOCKI will thus target three objectives: ? Demonstration of the mechanism of this reaction and determination of key parameters; ? Design of new reactions based on interrupted Hock processes, as supported by computation; ? Applications of Hock and interrupted Hock reactions in synthesis of valuab
Anticipating, deciphering, imicking molecular complexity of natural substances – ANTIDEPRIM
The project is structured in three «layers of knowledge« (cf title of the project) and aims to compare and analyze them in the era of «-omics« and megadata. The «field of possibilities« is explored by powerful anticipation tools invented in the consortium; biosynthetic pathways, results of evolution
Hydrogen driven enantioselective assembly lines – H2-drive
The quest for new eco-compatible enantioselective paths requires the orthogonal catalytic activation of multiple building blocks. The solution to this challenge calls for the design of innovative multi-catalyzed processes that is the ambition of this proposal. The proposed strategy is based on hydro
Catalysis in water by super hydrophobe hollow shells as solid micelles – CATCALL
• Se placer dans des conditions thermodynamiques favorables. La compréhension de la thermodynamique aux interfaces des différents constituants du système (solvant, réactifs, produits incluant les produits intermédiaires) est un problème complexe. En effet, ce type de problématique soulève de nombreu
Magnetoelectric Molecular Materials – MEMORi
Designing magnetoelectric materials is far to be straightforward owing to the phenomenological origin of both magnetism and ferroelectricity which tends to exclude each other. In addition, one of the key questions for future development concerns the mutual coupling between both properties in order t
Synthesis and applications of planar chiral photoredox catalysts based on a [2.2]paracyclophane scaffold – PhotoChiraPhane
As a consequence of their rigid three-dimensional structure, deck-substituted [2.2]paracyclophanes (pCps) can exhibit planar chirality and are nowadays considered as promising building blocks in organic synthesis. Nevertheless, the preparation of enantiopure poly-substituted paracyclophanes is often
Flow Chemistry for Room Temperature Switchable Particles – FlowSwith
FlowSwitch targets a new synthetic route for the synthesis of molecular functional materials coupling flow chemistry and supercritical fluids-assisted processes. Recent breakthroughs allowed to synthesize nanometric molecular switchable materials, operating at room temperature. For applicative devel
Asymmetric Remote Functionalisation Through Metallotropy – METALATE
Synthetic approaches for the construction of added-value organic molecules are in continuous progress. Until recently, the surge in cutting-edge synthetic approaches such as those based on C-H and C-C bond activations has produced a deep change in the way the chemist designs synthetic routes. And ye
Metal complexes for polymerization mechanism switching – POLYSWITCH
Synthetic polymers have found applications in many areas, ranging from most “basic” ones such as packaging to high-tech fields such as energy storage, aeronautics or biomedicine. The need of complex and precise architectures with specific monomer composition and enchainment requires living or contro
Molecular tools for structural studies of RNA methyltransferases – ARNtools
RNA methyltransferases (rMTases) catalyse methylation of RNA, most-often using S-adenosyl-L-methionine (SAM) as the cofactor. Frequently occurring methylations are the mono-methylation of adenine at position N1 (m1A) or N6 (m6A). This project aims at synthesising SAM-RNA conjugates as m1A and m6A rM
Intermetallic Electrides: New Promising Materials for Ammonia Catalytic Synthesis – Intermetalyst
The Intermetalyst project aims to explore in details novel supported catalysts based on electride-like intermetallics RTX (R = rare-earth; T = transition metal; X = Si, Ge) to enhance the catalytic synthesis of ammonia and hence reduce its energy consumption. Electrides are crystals that contain exc
Collective total synthesis of Grayananes and Kalmanes – SynCol
Grayananes and Kalmanes are two diterpenoid families produced by plants from the Ericaceae family. Grayananes have a tetracyclic structure with 5, 7, 6, 5 membered rings, while Kalmanes havee 5, 8, 5, 5 membered rings. The diversity in these broad families originates from the different oxidations at
Thioacid / Azide Ligation Applied to Nucleic acids as a new tool for chemical biology – TALAN
DNA templated chemical ligations are based on the specific pairing properties of complementary DNA strands. The latter are used to «force« the spatial proximity between chemical reactive groups of modified oligonucleotides (ODN) in order to dramatically accelerate a given reaction at very low concen
Selective modification of carbohydrates using photo-activated nanocatalysts – CARBOPHOTON
CARBOPHOTON aims at developing a photocatalytic procedure for the selective transformation of free sugars into their corresponding ester or amide derivatives. A preliminary study has allowed us to highlight the possibility of selectively and very rapidly oxidizing a wide variety of mono- and oligosa
Ring opening co-polymerization of succinic anhydride derivatives and epoxides from bio-based resources via organocatalysis – CoCaBio
This project aims at using organocatalysis for the ring-opening polymerization of biobased epoxides and succinic anhydride derivatives. The objectives are: 1) Synthesis of known (ureas, thioureas, squaramides, thiosquaramides) or unknown (croconamides) organocatalysts for their efficiency in othe
Chiral Cyclic Alkyl Amino Carbenes in Asymmetric Catalysis – ChiCAAC
In recent years the field of stable carbenes has witnessed outstanding breakthroughs and considerable developments. Due to their strong sigma-donating and pi-accepting character, and their simple, yet versatile synthesis, carbenes have successfully challenged the stronghold of phosphines in transiti
Carbo-silylation Reactions as Central Tool for the Synthesis of Complex Silaheterocycles – C-Sil
In this project, we would like to develop general and practical synthetic methods to make silaheterocyclic compounds readily available and easy to diversify in order to make these structures as tractable as other heterocycle families. To do so, we will focus our attention on domino reactions by taki
Asymmetric Synthesis of Allenes using Chiral Hypervalent Reagents - Application to the Total Synthesis of Protoilludane Natural Products. – HYPE4ALL
The developed methods will then be applied to the total syntheses of (+)-melleolide and (+)-armillasine, two natural substances featuring numerous biological activities. Our efforts have recently led to the development of a chiral organoselenium reagent capable of performing this transformation with
Thermomorphic Polyethylene-Supported Organocatalysts for the Valorization of Biomass and CO2 – ThermoPESO
With the depletion of the fossil carbon reserve and the need to limit emissions of greenhouse gases, the utilization of renewable biomass as a feedstock has become a necessity in the long term and a real challenge for chemists and biochemists. However, the use of the biomass implies that many techno
In silico approach for amine dehydrogenase discovery – MODAMDH
For biocatalysis to be a more applied alternative to conventional chemistry, it is essential to provide various templates in terms of sequences and structures. Even if protein engineering is a powerful method for evolving enzymes according to performance criteria (stability, substrate spectrum, etc.
Halogen ‘dance’ reaction in the ferrocene series to access rare although promising polysubstituted scaffolds – Ferrodance
The breakthrough discovery of ferrocene in 1951 has paved the way of metallocenes chemistry, a family of compounds in which two aromatics rings surround a metallic cation, here an iron ion. Prototypical compound of this family, ferrocene exhibits a high stability in various conditions and can even b
Flow photochemistry and Reactive Intermediates a win-win combination – FloRyn
The project FloRyn aims to develop versatile visible light photolabile presursors of non-isolable strained cyclic coumpounds that offers predictable access to short lived intermediates. Thanks to flow technology we will design a system capable of quickly delivering reactive/unstable compounds and ra
Atomic carbon source from C(0)-complexes – ATOMIC
Carbon, chemical element which generally constitutes the structural body of organic compounds, is, without any doubt, one of the most important elements in organic and organometallic chemistry. Classically, organic synthesis involves the coupling together of small building blocks to get access to
Expedient synthesis of 3-aminoglycals and derivatives via redox relay strategy – AWACOS
This project describes an expedient and scalable synthesis of 3-aminoglycals. 3-aminosugars are a class of rare glycosides of high relevance that can be found on a large number of bioactive compounds. As an example, 3-amino-2,3,6-trideoxyhexoses, L-rhodosamine , L-daunosamine and L-ristosamine, are
Asymmetric Brønsted Acid-Catalyzed Cyclization involving Alkyne Activation – BAC-C
The BAC-C project deals with the development of an original methodology of enantioselective formation of carbon-carbon bonds by an electrophilic activation of alkynes towards nucleophilic attack in the presence of Brønsted superacids organocatalysts. The use of these catalysts allows the selective p
Catalytic Properties of Molecular Systems Combining Porphyrins and N-Heterocyclic Carbene-Metal Complexes – COmPaCt
In the context of increasing energy demands and environmental problems, using photocatalysis and electrocatalysis to obtain valuable chemicals or fuels is receiving increasing attention and will probably become a ubiquitous challenge in the future. Porphyrins and N-heterocyclic carbenes (NHC) are tw