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Exploitation of antagonistic traits of E. coli Nissle 1917 to reduce carriage and spread of ESBL plasmids in intestinal enterobacteria – EcN-ReduceESBLEcoli
This project aims at the establishment of Escherichia coli Nissle 1917 (EcN)-based approaches to interfere with resistance plasmid transfer and to clear ESBL-producing E. coli from the intestinal microbiota. This well-established probiotic is competitive due to different antagonistic activities, inc
EFFlux pump inhibitors to Overcome antibiotic ResisTance – EFFORT
The main objectives of EFFORT are to define the mechanism of action of the new efflux pump inhibitors, develop structural biology knowledge on Gram negative efflux pumps and to develop the inhibitors into drug like molecules for in vivo proof of concept studies. This research program will aim de
Specific Inhibitors of Aminoglycoside Modifying enzymes – SIAM
Sur la base de notre connaissance des structures et spécificités des enzymes de modification des antibiotiques APH, nous proposons de concevoir des inhibiteurs spécifiques capables de restaurer la sensibilité bactérienne aux aminosides sans affecter les kinases humaines. Le projet s'appuie sur des é
Antifungal Resistance: From Surveillance to Treatment – AReST
Invasive fungal infections are an underestimated health problem, which is exacerbated by their difficult diagnosis and an increasing emergence of resistances to the few antifungals currently in use. Among the most common fungi in France and Germany causing systemic mycoses with high mortality rates
New Antibiotics Tackling mUlti-Resistance by acting on Alternative bacteriaL tARgets in Synergy with mEmbrane-disruptiNg AntimicrobiaL peptides. – NATURAL-ARSENAL
NATURAL-ARSENAL (New Antibiotics Tackling mUlti-Resistance by acting on Alternative bacteriaL tARgets in Synergy with mEmbrane-disruptiNg AntimicrobiaL peptides) aims at characterizing the action of new classes of antibiotics from myxobacterial and actinobacterial strains in carpapenem-resistant Gra
Rational beta-lactam/beta-lactamase-inhibitor-based combination therapies of last-resort antibiotics to maximise efficacy and protect against emergence of resistance – CO-PROTECT
Novel and structurally diverse beta-lactam - beta-lactamase inhibitor (BL-BLI) combinations displaying activity against multi-drug resistant (MDR) Gram-negative bacteria have recently become available including ceftazidime-avibactam, ceftolozane-tazobactam and meropenem-vaborbactam. Despite their li
Pre-clinical mechanistic assessment of two bacteriophage cocktails targeting multidrug-resistant Pseudomonas aeruginosa and Escherichia coli for the treatment of ventilator-associated pneumonia – MAPVAP
Nosocomial infections cause high morbidity and mortality rates among hospitalized patients. Ventilator-associated pneumonia (VAP), defined as pneumonia that occurs later than 48 hours following endotracheal intubation, is characterized by high incidence (9-27% of all mechanically ventilated patients
Transmission of Antimicrobial Resistance by GEne Transfer within Bacterial Biofilms – TARGET-biofilms
Bacterial communities are composed of a variety of species, which have the ability to exchange genetic material through horizontal gene transfer (HGT), thus accelerating their diversification, adaptation and genetic evolution. The major gene transfer mechanism is bacterial conjugation, where DNA is
