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In the field of biomedical analysis, current macroscopic methods based on chromatography techniques coupled to mass spectrometry remain long and tedious, which may prove detrimental for certain pathologies such as innate errors of metabolism where a fast and early diagnosis is often desired. On-chip

An important issue of this study is to explore physical possibilities to access optical information in thick biological tissue. The objective is to be able to measure the parameters of intraneuronal transport in complex and mature networks, in order to compare different conditions. The microscopy se

Industry is currently taking the lead to develop applications based on the genuine properties of Single Walled Carbon Nanotubes (SWNTs), that are their outstanding strength and aspect ratio, and ability to display metallic or semi-conducting characteristics, depending on their chiral structure. From

The central objective of the HyMag project is to develop new chemical and instrumental approaches to generate > 1000 fold sensitivity enhancements in NMR and MRI, on solutions of molecules with high throughput and in a quasi-continuous flow manner for the very first time. This will be made possible

Prussian blue (BP) nanoparticles (NPs) doped with manganese are particularly interesting for theranostics. Indeed, these NPs have remarkable properties as contrast agents in magnetic resonance imaging and an exceptional photothermal conversion effect which means that these NPs can cause a localized

Efficient coupling between electronic and biological systems requires an interface for converting electronic signals into ionic (or chemical) signals, and vice versa, ideally with high sensitivity and speed. Unfortunately, the performances and functionalities of present electro-ionic devices poorly

Chirality, a fundamental property of molecules, lies at the heart of biochemical processes. It influences the characteristics and functions of biomolecules, from amino acids to proteins. Understanding how biomolecules interact with surfaces is crucial for various applications, such as anti-bacterial

Our first objective is to synthesize the two types of stimuli-sensitive ligands: the 1st based on temperature-sensitive polymers such as pNIPAM, and the 2nd based on ß-cyclodextrin/guest interactions, whose affinity is sensitive to electrochemical or optical stimuli, depending on the nature of the g

Precise temperature measurement at the submicrometer scale is an important challenge encountered, namely, in the fields of nanotechnology and nanomedicine. Thermometers working in an accurate, non-invasive way and with a high spatial resolution are critical to monitoring numerous processes at the mi

Nanoobjects are more and more subject of interest in academic and industrial research. However, most of the studies essentially focalize on the properties of individual objects. Indeed, a key challenge to study collective properties – opening doors to new applications – is the organization of such o

Sepsis, blood bacteremic infection, is one of the main mortality causes in the world. It is essential to treat sepsis as quickly as possible since the chances of survival decline by 7% each hour. As current sepsis diagnosis require several days, broad-range antibiotics are massively used in a first

COCOsMEN project deals with the synthesis and in depth study of hybrid nano-objects made from gold or silver nanoparticles, of various sizes and shapes, on which coordination complexes are grafted. Such architecture is proposed to enable synergy between the localized surface plasmon resonance of the

With the rise of nanosciences, nanotubes have been recognized as an ideal platform for fundamental confinement research. They have been suggested as promising building blocks that could outperform current technologies for nanofluidic, molecular sieving or energy storage. In the meantime, the concept

Metal-Organic Frameworks (MOFs) are ideal materials for the modular design of complex assemblies, as they possess a long-range ordered hybrid structure associated with well-organized micro- or mesoporous channels and/or cages. Their chemical composition (metal cation, ligand) can be easily tuned, th

One of the strengths of the field of nanomedicine is its promise to bring new therapies to a site, by remote activation of nanomaterials to produce for example heat or chemical reactions, while reducing side effects. The current challenge of these "physical nano-therapies" is to improve their therap

INSOMNIA aims at promoting at the Institut Charles Delaunay (UTT-CNRS), through the JCJC financial grant, a new research field at the frontier between nano-optics and mechanics. The scientific goal is twofold: i) controling optical properties of nanoparticle assemblies depending on their displacemen

NANOFUELCELL aims to the development of bioelectrodes based on confined solutions of supramolecular assemblies of redox mediator and enzymes or enzyme assemblies. The electrical wiring of enzymes in solution with electrodes forming a permeable chamber will be ensured by supramolecular assemblies of

The main objectives are 1. Identification of most promising anti-MERS-CoV nanostructures using in vitro tests 2. Determination of the pharmacokinetic of the best nanostructures 3. Pulmonary delivery using nebulization of mice 4. Testing of most promising anti-MERS structures in MERS-CoV infecte

Technically diverse super-resolution imaging modalities are now routinely available, such as stimulated emission depletion microscopy (STED) or structured illumination microscopy (SIM). Currently, the most widespread and commonly used methods are single molecule localization microscopy (SMLM) approa

An adult living in today’s industrialized countries is confronted with dozens of microchips a day, in the form of everyday life objects, such as phones, glasses, domestic appliances. We are experiencing what we can call a real "digital invasion", a phenomenon that goes to accentuate in the coming ye

The aim of this project is the rational design of novel electronic devices, transistors or sensors, based on two-dimensional transition-metal dichalcogenides (TMDC), such as MoS2 and WS2. In these devices the density and mobility of charge carriers in the 2D materials is controlled through ionic-liq

Development of fouling-resistant smart membranes selective for challenging protein separations is needed since separation of similar-sized proteins with current commercial membranes is not possible. The AFM_Ring project proposes a membrane skin layer design breakthrough, which consists of a well-ord

Delivery systems, especially nanoscaled systems, that allow for a non-invasive control of the release of bioactive molecules in living organisms are highly sought after. Such approaches are not only of interest in basic sciences but they would also open exciting perspectives for the treatment of dis

The human body is increasingly exposed to carbon nanotubes and graphenes, as well as two-dimensional analogues, that are developed for industrial use or medical purposes. However, still little is known on the life cycle, long-term fate and potential toxicity in the body of such 1D and 2D nanoparticl

The main goal of the experimental PRCI research project HARVESTORE is to develop a compact versatile vibration energy-harvester power source and energy storage devices based on nanomaterials, nanostructuration and functionalization and their integration, thanks to a specific electronic system, for

Multiferroics are multifunctional materials that have acquired this denomination in 1994 at the moment of the revival of their studies. Since then more than 10,000 articles have been published on all the aspects of this interdisciplinary topics. The interest for these materials that combine (anti-)f

The main challenge targeted by the ULTiMeD project is to gain an atomic level control over an innovative fabrication of sulfide-based lamellar materials and ultimately 2D transition metal dichalcogenides (TMD), a recognized class of emerging materials of large potential in microelectronics. The orig

STACSAMGRAPH project aims to expand the field of van der Waals (vdW) heterostructures, that is to say two-dimensional (2D) materials assembled layer-by-layer where the monolayers are held together by van der Waals forces. Here, will be developed a novel kind of vdW heterostructures alternating at

Foams, emulsions, pastes, porous media, biological suspensions or living tissues, are involved in many industrial processes and are largely studied since several decades. However, mainly two questions are still a challenge for the physicists: the stability and the dynamic of these systems. These que

Lignocellulosic materials, generated in large amounts from agricultural practices, are one the most promising renewable feedstocks available for human exploitation. Lignocellulose mainly contains polysaccharides such as cellulose and hemicelluloses. Its biological conversion with enzymes is very att

UP-DOWN project aims at laying the basis for the design of next generation nano-transducers and mechanical actuators based on ferroelectric materials controlled by light. For this, the mechanism of ultra-fast photostriction (control of the deformation by light) will be studied from the fundamental p

Self-assembly is the process by which elementary building blocks spontaneously form organized structures of a higher level of complexity. Being able to master these emerging structures and their properties is of great fundamental and applied importance in research worldwide. Soft matter is playing a

Although upper critical solution temperature (UCST) polymers have an interesting potential for drug delivery applications, their use has been hampered so far by their lack of degradability. The goal of our project is to synthesize biodegradable diblock copolymers with UCST behavior based on PEGylate

In the context of the research in innovative and efficient systems for both treating and detecting diseases, NanoParticles (NPs), because of their nanoscale size, offer the opportunity to: i) improve in vivo pharmacokinetic by extending circulation time and ii) to modify biodistribution by targeting

Our goal is to develop appropriate technological processes to isolate large area single MXene flakes with tunable surface functionalizations and to characterize their properties – mostly electronic – . The end goal is to obtain a quantitative and qualitative overview of the intrinsic properties of f

Metallic nanowire (MNW) based transparent electrodes (TE) have attracted recently a great interest since they represent a cheaper and versatile alternative to conventional oxide TE. MNW based TE appear to exhibit very good optical and electrical properties, very good bendability and a low price comp

Quantum dots (QDs) exhibit unique photophysical properties as narrow and size-tunable emission, broadband absorption and high fluorescence quantum yields (QY). Hence, QDs have already been integrated as color converters into the white backlight of LCD displays used in high-end television screens by

Metallic FCC-BCC nanolayers, such as Cu/Nb, have received wide attention due to their extraordinary mechanical properties as well as the unique self-healing capacities due to the interface characteristics. Most recently, the materials have also been shown to exhibit significant and tunable interfaci

The main goal of the PANASSÉ project is to develop cold emission cathode technology based on an innovative planar nanowire structure, the production of which is controlled by a buried electrode in the carrier substrate. For this goal, we have to develop several bricks, namely the production of nano

The main goal of the LIGNEDEMIR project is to develop InAlGaAs quaternaries lattice-matched on InP with monolayer control of composition and interface abruptness using MOCVD. These quaternaries give an added degree of freedom in the design of intersubband devices based on the InAlAs/InGaAs/InP mater

The discovery of localized surface plasmon resonances (LSPR) in doped semiconductor nanocrystals (NCs) has opened a new field in plasmonics. As an emerging new class of plasmonic nanomaterials, doped semiconductor NCs with LSPR has received great attention in the past few years, with recent pioneeri

Nanoscale noble-metal particles have broad applications in catalysis, health sciences, molecular electronics, optical devices, etc. Among this large category of compounds, ligand-protected atom- and electron precise nanoclusters (NCs) known as superatoms are of prime fundamental importance owing to