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Abstract of my project submitted to the ERC-STG-2017 call The ever-increasing amount of geophysical data continuously opens new perspectives on fundamental aspects of the seismogenic behavior of active faults. In this context, studying the interrelation between seismic and aseismic fault slip is
Molecular humanization of synapses: development and plasticity
The human brain is the result of a long evolution that has shaped its development and built its complexity. So are human synapses, the brain’s smallest subcellular units. The goal of this project is to understand the mechanisms underlying synaptic development and evolution, and determine how the hum
Development of the human neocortex: deciphering the molecular mechanisms of neural stem cell proliferation
Expansion of the neocortex during evolution has played a key role in the appearance of higher cognitive functions in humans. Neocortex development occurs via proliferation of neural stem cells that generate all neocortical neurons, and developmental defects can lead to severe cortical malformations.
Highlighting the dark part of light-matter interactions
Light and matter interactions are widely considered to be mediated solely by the electric field part of light, neglecting the other major component of electromagnetic waves. This is particularly relevant in quantum optics where the electric field component of the light couples to the electric dipole
Fundamental Thermoelectricity with Mesoscopic Circuits
It is now well established that the amplitude of the electric conductance is set by fundamental constants. Its natural unit is the ratio of the square of the elementary charge to the Planck constant, and is known as the quantum of conductance. When charge flows in a mesoscopic system, electric condu
Motif repeats in intrinsically disordered regions of the clathrin mediated endocytosis pathway
Linear motifs are short sequence stretches that occur in intrinsically disordered protein regions (IDRs) lacking stable secondary and tertiary structure, and mediate vital interactions within various biological systems. An exemplary system for the presence of IDRs and a high concentration of linear
Molecular Approaches to Multifunctional Ferroelectric Materials
Ferroelectric materials built up with molecular entities are at the forefront of condensed matter chemistry and physics. Key challenge facing these materials is engendering outstanding polarization coupled with multifunctionalities. Tackling this challenge requires synthetic chemistry focused on new
Deep Serpentinization and high-pressure abiotic methanogenesis
The goal of this project is to understand the geological processes responsible for the generation, migration and consumption of deep abiotic hydrocarbons, in particular methane (CH4), formed by alteration of ultramafic rocks at high-pressure conditions. Alteration of ultramafic rocks is a well-know
Evolutionary history and genetic adaptation of Plasmodium vivax
Summary submitted at the ERC-Stg-2017: Infectious diseases represent the second cause of death worldwide despite the remarkable advances in their management and in medical research during the 20th century. One reason is the periodic emergence of new infectious diseases in human populations. The bot
Background: Individual performance of surgeon is a core element of successful surgery that can vary greatly over career for poorly understood reasons. Solutions to optimize physical and mental condition of surgeon during operation have not been thoroughly explored so far, while this may represent ba