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DynaSweet a pour objectif de concevoir de nouveaux systèmes moléculaires capables d’inhiber l’adhésion de pathogènes sur des cellules, premier évènement du processus d’infection. Pour cela deux équipes de chimistes sont en charge de concevoir des briques moléculaires qui pourront s’auto-assembler en

The goal of this research proposal is firstly to synthesize a new family of compounds, the hypervalent iodosulfoximines, and secondly to study their properties especially as electrophilic (enantioselective) sources of perfluoroalkyl moieties as well as a source of fluorinated radicals. The group o

These types of product have never been obtained from CO2 by chemical means. The goal is thus to find the right strategy to achieve such goal. We could prove that the strategy used indeed gives rise to a C3 carbohydrate with CO2 as the only source of carbon. A complete mechanitic experimental and the

The aim of the project was to synthesize new molecular interlocked architectures named foldarotaxanes. These structures consist in a molecular axle that is surrounded by a macrocycle and a foldamer. Once the chemical access validated, we have studied the influence of the macrocycle (its presence and

The ultimate objective of the proposal is the development of low-cost solution-based strategies for the synthesis of iron silicides nanocrystals (NCs) featuring controlled-composition, -size, -surface, and -shape. However, given the synthetic challenge, iron and cobalt germanide have also been studi

Usually, the two functions of a bifunctional catalyst are randomly distributed and its catalytic properties are maximized varying their respective amounts to get the so-called ‘ideal balance’. Such approach does not explicitly consider the distance between the two functions. The only condition is to

The project Cellmach aims at the design and fabrication of molecular machines consisting in a “motor” moiety coupled to nanocellulose as the “arms”. Molecular machines are nanometer-sized systems that convert energy from external stimuli (heat, ionic force, radiation) to motion. Despite their outsta

The microbial biosphere represents the largest reservoir of catalysts for future industrial application. Yet it remains largely unexplored, with also the majority of genes identified in metagenomes still of unknown function. Using dehalogenation as a key major function with high-potential, versatile

The objective of the DEFIS project is to develop effective synthetic methods to access a wide variety of compounds, chiral and in optically enriched form, incorporating an emerging fluorinated group, in particular a difluoromethyl, trifluoromethoxy or pentafluorosulfanyl substituent. The first wor

La synthèse de nano-aimants chiraux 1-D (appelés chaine-aimants ou Single-Chain Magnets et notés SCMs) construits à partir de complexes 4d ou 5d énantio-purs est spécifiquement ciblée pour démontrer ce concept. Des complexes métalliques d’ions 4d/5d sont des alternatives aux éléments du bloc f pou

The hydrogenation and amination of bio-based molecules usually require catalysts based on noble metals (e.g. Pd, Pt). However, due to the cost of noble metals and their decreasing availability, it would be interesting to use non-noble and less expensive metals, such as molybdenum, tungsten and vanad

Molecular electrophilic regions observed at halogen (Hal), chalcogen (Chalc) and pnictogen (Pnic) atoms, also called Sigma-Holes, are preferential anchored sites targeted by molecular partners bearing nucleophilic groups. Interactions involving Sigma-Holes are highly directional, while the intensiti

Phosgene (Cl2C=O) is a black spot for the chemical industry. On the one hand, phosgene is the key electrophilic reagent in the production of organic carbonates, polycarbonates and polyurethanes. On the other hand, its intrinsic toxicity and the HCl emissions from its utilization induce a dramatic ad

The hydrogenation of sugars into polyols is often carried out on noble metals such as ruthenium Ru or on Raney nickel, with little work reported on supported non-noble metals. However, the cost of noble metals is high, their abundance is low, and both their cost and availability are prone to large f

Thanks to the preliminary works of each partners, their own knowledge on astatine and anion capture chemistry and because properties of astatide anion are weakly known, we propose a depth study of this anion behavior in the context of supramolecular complexation by weak binding interactions in order

Mimicking and engineering efficient biomimetic processes have been a long-standing goal of the scientific community. In particular, access to artificial enzymatic systems enabling complex chemical transformations to be performed is one major challenge. Indeed, broadening enzyme reactivity to transfo

The chemistry of the large alkaline-earth metals (Ae, where Ae = Ca, Sr, Ba) is burgeoning. Many synthetic challenges persist to this day, although Ae complexes act as excellent catalysts for a plethora of organic reactions. In another field, silicones exhibit good fire-resistant properties owing to

This project aims at developing and studying a novel class of polyethylene aerogels, i.e. nanoporous, hydrophobic and ultralight materials from commodity components, with high efficiency as thermal insulators. The relationships between chemical reactivity of the precursors, architecture of the poly

Osteoarthritis (OA) is the most common joint disease, characterized by gradual loss of articular cartilage due to abnormal extracellular matrix (ECM) and changes in chondrocyte morphology and metabolism, associated to sub-endochondral bone remodeling and local synovitis. The burden of this disease h

ALCACAT assembles two complementary teams at University of Rennes 1 (Dr. Y. Sarazin (coordinator), Prof. J.-F. Carpentier, Dr. E. Caytan) and University Paris-Sud in Orsay (Prof. V. Gandon, Dr. C. Bour, Dr. D. Leboeuf). The project revolves around catalyst engineering via coordination chemistry of t

The challenge of achieving absolute asymmetric catalysis in a rational and predictable manner was achieved by dissociating the catalytic and symmetry breaking / chirality amplification phenomena required for the emergence of single chirality. More precisely, asymmetric metal catalysts have been supp

Exposure to visible light of certain white wines, rosés and champagnes induces the formation of an organoleptic fault known as the light-struck flavor. The latter is characterized by smell of cooked cabbage, or wet wool and rotten eggs, as well as accentuated bitterness in the mouth. This defect can

The TECH project aims to transpose the knowledge and know-how developed for the development of extracellular electron transfer (EET) with microbial biofilms to forge the necessary tools to identify EET with human cells. Connecting metabolic pathways to electrochemical analytical systems could be th

The role of RNA in cellular processes is one of the most dynamic and fast growing fields in biology. Chemistry driven analyses of the biological role of RNAs requires synthetic methodologies to modify their structures. This field is notoriously underdeveloped due to RNA instability. Our objective is

Carbon black particles are the most widely used nanoparticles in rubber to reinforce tires. Their production contributes much to air pollution and to the greenhouse effect. The introduction of silica particles in tires, to replace partially carbon black particles, is therefore a major ecological adv

THERAPEPTICS is a bio-inspired chemistry project which aims at synthesizing new amino-acid polymers, called peptidomimetics, as simplified analogues of natural antimicrobial peptides (AMPs). The main objective of this project is to study their antibiotic potential against the bacterium Clostridium d

Ynamides are molecules bearing a CC triple bond directly linked to a nitrogen, which bears an electron-withdrawing group. They readily react with tetracyanoethylene to afford molecules named tetracyanobutadienes (TCBDs) after a cascade reaction. Thanks to their four nitriles groups, these compounds

The SCoopCH project aims at designing new and sustainable approaches for the transition metal-catalyzed functionalization of aromatic and aliphatic derivatives with various SRf groups (SCF3, SCF2H and SCF2FG) by C-H bond activation. To reach that challenging goal, we intend to bring eco-friendly sol

This project aims to study the fundamental chemistry of mesoionics, an underrated family of heterocyclic dipoles, toward strained cycloalkynes in order to synthetize new helicenes and tetraphenylenes. The first results of this project have confirmed the hypothesis. A series of complex poly-heteroaro

The real time monitoring of oxidative stress and its imaging by MRI and optical techniques is an emerging field, as it has applications both in diagnostic and therapy. The oxidative stress, i.e. the “disruption of cellular redox homeostasis” is believed to favor some of the main pathologies of the 2

In the field of data processing, the need for ultra-miniaturizable optical gates requires developing new molecular materials for such a task. To this end, our goal is to design novel molecules for «all-optical« switching controlled by multiphoton absorption. The challenge consists in designing syste

Currently, work in the field of switchable ligands and catalysts pursues the major objective of controlling complex multicatalytic sequences by an external stimulus, such as light. The originality of our project compared to the previous work of the literature, consists in targeting bimetallic comple

When metal nanocatalysts operate in a gas environment, the density of catalytically-active surface sites is driven by both intrinsic (nanoparticle size, composition and morphology) and extrinsic parameters (nature of catalyst support and reaction conditions). Moreover, the site density varies dynami

Alzheimer’s Disease (AD) is a worldwide pandemic. This multifaceted, progressive neurodegenerative disease is characterized by progressive cognitive decline and memory loss and no solution is presently available for curative treatment. Specific mutations in APP or PS1 have been described representin

This project is focused on the development of (fluorescent) nanoparticles for biomedical applications in cell imaging and therapy. The objective of the SUPERFON project is to screen and intensify the supercritical antisolvent (SAS) precipitation process of organic fluorescent nanoparticles (FONs), t

Synthetic inhibitors of viral sialidases (SA) were particularly developed and this was rewarded in the field of anti-influenza drugs by the licensing of zanamivir (Relenza®) by GlaxoSmithKline and oseltamivir (Tamiflu®) by Hoffman-La Roche. These two last examples validates the potential importance

NANOTRAP aims at developing a new concept for deconstructing complex biopolymers like lignin into valuable chemicals. Indeed the valorization and refining of biomass still represent a great challenge from both scientific and economical points of view. The main requirements for the full development

Terephthalic acid, an important precursor for the polyester fiber, resins, PET bottles, PET films and food additives industry, is produced at the level of 3.9 million tons every year throughout the world. The synthesis of aromatic carboxylic acids of interest such as terephthalic acid often implemen

The increasing use of plastics based on petrochemicals has raised international environmental and ecological difficulties in recent years, due to the dependence on petroleum resources and to the lifespan of these materials linked to their weak degradation. This problem motivates current research to

Indole is a readily available high tonnage aromatic compound but its synthetic utility remains under-exploited. We propose the development of new methodologies for its de-aromatization via difunctionalization reactions. This will allow to obtain efficiently and rapidly original functionalized three-

The beginning of this century is clearly marked by profound social changes. Indeed, while considering, on one hand, the continuously growing worldwide population and, on the other hand, ecological issues and depletion of natural resources, we are facing an urgent need for refunding our industrial pr

Anti-UV compounds represent a huge market in the cosmetics industry for their ability to protect humans from sun damage. Unfortunately, the current anti-UV compounds used in cosmetics (eg octinoxate) are criticized for their toxicity on the endocrine system and their allergenicity, as well as their

Biosynthetic hypothesis has been emitted for their origin based on the condensation of an oxidized form of xerocomic acid and involving a complex cascade of skeletal reorganization. The overall objective of this project is to develop a synthesis of the highly intricate frameworks of sclerocitrine an

Reducing agents with neutral organic structures and exceptionally negative redox potentials have received a renewed interest especially since the astonishing advances of their reactivity in organic chemistry. Strong organic electron donors (OEDs) are capable of spontaneous single- or double-electron

In the field of smart materials, photoswitchable multichromophoric systems are prone to show fluorescence hysteresis effects, unexplored to date. The SWIST project proposes to design well-structured molecular architectures composed of a large number of fluorescent and photochromic units linked to a

Conversion of biomass to biofuel or other valuable products can be achieved via selective conversion of individual components of biomass. In such cases, the process was established based on using a bioplatform molecule as starting material. Now, it is necessary to develop new bioplatform molecule in

The chemical analysis of specialized microbial symbionts yields a deeper understanding of the evolution of symbiotic systems, and at the same time grants access to intrinsically bioactive natural products. It is only now that the impact of these natural products on the discovery of novel antibiotics

Inspired by Frustrated Lewis Pairs and cooperative catalysis, the CasPair project will study new catalysts in which the inclusion of a Lewis partner inside a cavity controls frustration of a Lewis pair to form an unexplored Cavity-Separated Lewis Pair (SLP). The congestion of the reactive center ins

The HyperSiLight research program focuses on the development of new radical precursors based on anionic and cationic hypervalent silicon derivatives that are easily accessible, bench stable and should allow the generation of a variety of radicals under mild oxidative or reductive photocatalytic cond

Non-canonical DNA and RNA structures, such as G-quadruplexes (G4) as well as hairpin-like, slipped-strand structures formed by tri-, tetra- and oligonucleotide repeats in DNA and RNA, represent therapeutically important targets whose biological functions can be modulated using small-molecule ligands

Since the pioneering work of Akiyama and Terada in 2004 on BINOL-derived chiral phosphoric acids, a huge amount of efforts worldwide has been devoted to the development of elaborated C2-axially chiral catalysts including sterically crowded atropisomeric BINOL, VAPOL or spirocyclic SPINOL derivatives

The production of custom-made functional biomaterials using sustainable synthetic processes is an important challenge for modern society. Nature provides inspiring examples of biomaterials which are self-fabricated in a bottom-up fashion through hierarchical self-assembly. Here we propose to investi

The development of high-performance biomaterials and goods from forest and agricultural biomass via environmentally responsible processes are central to a sustainable bio-based economy. The vision of this joint French-Canadian (ANR-NSERC) Partnership Project is to harness fundamental insight, gained

The production of high-added-value molecules from biological resources often involves the chemical transformation of the bio-sourced material to allow its conjugation to a molecular platform, a drug or a carrier. The advent of bioorthogonal conjugation techniques together with metabolic glycan engin

The objective of this proposal is to incorporate phosphorus- based electronic components into organic field effect transistors (OFET's), and to evaluate these devices as sensors for organophosphate pesticides and Weapons of Mass Destruction surrogates (WMDS). The work will also provide optimized met

The present proposal will provide important answers to fundamental questions about electron transfer at interfaces and electron hopping between redox centers of different nature assembled in a supramolecular architecture. The preparation of giant rotaxanes will rely on development and adaptation of