Search
Understanding cellular variation of 3D genome organization using novel Nanopore-sequencing-based Chromosome Conformation Capture assays. – Nanopore 4 3D-Genome
Below, my abstract as provided in my ERC-StG project is provided: To understand the mechanisms of gene transcription and regulation, the essential functions of tridimensional (3D) genome organization in these processes need to be dissected. Our current knowledge of 3D organization is incomplete b
- epigenome, transcriptome, chromatin architecture – Three dimensional crop responses to heat stress: a case study on wheat – 3DWheat
Due to climate change, heat stress is going to become a major source of yield loss in Europe in the coming years. There is thus urgent need for the elucidation of cellular mechanisms involved in heat stress response to be able to produce new varieties with improved tolerance. Although the mechanisms
Exploration of the biodiversity of magnetotactic bacteria – BIOMAGNET
During the course of evolution, environmental changes deeply modified ecosystems in which microbial communities rapidly adapted. To predict the impact ecosystems have on bacterial biodiversity requires both to follow evolutionary history of valued functions/traits in different ecosystems and to obta
Cortical Actomyosin Dynamics in Development and Morphogenesis – CADMO
The cortical actomyosin cytoskeleton is a major determinant of the mechanical properties of embryonic cells and tissues. Spatial and temporal modulations of these properties define the mechanical landscape that drives morphogenesis. Yet, an integrated view linking the biochemical properties of the c
Mimicking the strategy of marine species to develop biomaterials for tackling UVR-induced damages – OCEAN STAR
The resulting higher exposure of the Earth surface to ultraviolet radiation (UVR) is a threat to living systems owing to the damage caused to biological molecules. Without adapted measures to prevent the decline of ozone layer and changes in populations’ behaviour (overexposure to sun) and without f
Combinatorial Selections of Structure-Specific Nucleic Acid Binding Ligands – CASTing
Nucleic acids represent strategic molecular targets to understand and combat pathological disorders. The development of highly selective probes and drugs to detect and disturb nucleic acid related processes is then of profound importance to fundamental biology, clinical diagnostics and therapeutics.
Neural stem cells proliferation during normal and pathological brain development – NEURODEVO
Development of the neocortex occurs via proliferation of neural stem cells that generate all neocortical neurons. The central goal of this project is to understand how proliferation of different pools of neural stem cells is controlled both spatially and temporally to allow proper formation of the
Neuronal UltraSound Stimulation – Understanding and control of the biophysical mechanisms toward applications to sensory handicaps – NeUStim
The only way to artificially induce brain activity has long been electrical stimulation. This technique is well-established for the management of various diseases (Parkinson's disease, pain, epilepsy, treatment of deafness). Electrical stimulation techniques require the placement of subdural electro
Decoding the complexity of astrocyte reactivity in neurodegenerative diseases – DecodAstro
Astrocytes have long been neglected in the field of Neuroscience. Now that their multiple roles in brain physiology are recognized, the next challenge is to understand their implication in disease. Astrocytes become reactive in virtually all pathological situations affecting the brain. This response
Quantum magnetism of high spin fermions – HIGHSPIN
I suggest to study collective effects in ensembles of strongly interacting large spin atoms trapped in periodic potentials. The study of quantum magnetism of these large spin particles will extend the possibilities offered by spin ½ electron gases and effective spin ½ atoms. Our experiment will repr
Space and Time Control of Surface Waves – SurfWaves
Wave control has undergone remarkable developments during the last decades as it has applications in many fields from medical imaging to telecommunications or seismology. Controlling wave propagation in complex media faces major challenges: their design and fabrication is out of range due to the spa
Towards secure and private personal-data-based online services in the networked world – CONNECTED
The Internet has become essential to our lives and economies. In particular, it supports a host of personal-data-based online services that we use in almost all our daily activities (for recommendations, social networking, etc.). Thanks to the collection of large amounts of personal data about indiv
Improve the understanding of strategic communication and the design of information environments from both a theoretical and experimental perspective on verifiable information N/A N/A N/A The importance of hard information for communication has been growing with recent technological evolutions as inf
Reconstructing the life of massive galaxies through artificial intelligence in the big-data era – ASTROBRAIN
Understanding how galaxies form and evolve is an unavoidable step for humanity in quest for its origins. Galaxies in the past were small, dense and irregular. Today they conform the well known Hubble sequence. Linking the two populations is the key and the founding driver of this proposal. We have
Single-molecule chemical reaction with surface-enhanced coherent anti-Stokes Raman scattering – SiSeCARS
Surface-enhanced Raman spectroscopy (SERS) is becoming an important analytical tool because it has low detection limits allowing single molecule detection and can provide signal enhancements of the order of 104 -1015 with respect to Raman scattering. However, major challenges are limiting SERS in se
Shaping the Dynamics of Network Diffusion Processes – NDFUSION
Network diffusion processes -- that is, the dynamics by which some information, behavior, or condition starting out with a single or a few individuals, propagates through the network to reach a potentially much larger number -- are ubiquitous in social, biological, and technological networks. The sp
Analysis ot the Geometrical Effects on Dispersive Equations – ANADEL
We are concerned with localization properties of solutions to hyperbolic PDEs, especially problems with a geometric component: how do boundaries and heterogeneous media influence spreading and concentration of solutions. While our first focus is on wave and Schrödinger equations on manifolds with bo
Lipid Droplet Consumption during Energy Needs – LDEN
Lipid droplets (LDs) are intracellular oil droplets regulating energy metabolism. Excess LDs is responsible for obesity and metabolic disorders affecting all human tissues. Regulating LD consumption is crucial. Recently discovered, lipophagy is a LD consumption mechanism by macroautophagy: a dou
From optimal to biological theories of choice: identifying neural coding constraints on decision making in the human brain – DECODE
Making decisions, from simple perceptual judgments to complex policy-making orientations, often requires to combine multiple pieces of ambiguous or conflicting information. In such conditions, human choices exhibit a suboptimal variability whose origin remains poorly understood. Dominant theories at
Vigilance and Credulity in Human Communication – VICCOM
Humans have been berated for their poor abilities to evaluate communicated information, be it credulity—accepting the costly messages of demagogues or marketers—or conservativeness—refusing to accept valuable ideas in favor of instinct and tradition. Contemporary psychology provides experimental res
Nuclear envelope attachment and dynamics of Human telomeres – teloHOOK
The spatial and temporal organization of the nucleus and its components are essential for genome regulation. During interphase of mammalian cells the nuclear envelope maintains the shape and the mechanical integrity of the nucleus, but also provides an anchor for chromatin that is connected to its i
Single electron detection in Transmission Electron Microscopy – e-See
The ultimate goal of device miniaturization is to rely on a single charge provided by a single dopant atom: solotronics. Currently the gate length in a transistor cannot be reduced beyond 10-12 nm, as variability between nominally identical devices reaches unacceptable levels. Elaborate quantum tran
Organizational Design Choices: Exploring Micro-Foundations and Multidimensional Goals – ORGDESIGN
I set out to develop a new coherent framework of governance and design choices in organizations. The state-of-the-art theory and empirical evidence guiding scholars of this area have important limitations. Within the scope of this proposal, two most important limitations guiding the intended contrib
Study of the Emerging Properties Arising at the Scale of the Embryo Driving Tissue Morphogenesiss – SEPASEDTM
The goal of the project is to understand how biophysical forces are generated and how they work to produce exquisitely precise and controlled tissue shape changes in embryo development. Tissue morphogenesis is a process by which the embryo is reshaped into the final form of a developed animal. Tissu
Deep Earth Water Transport – DeepW
Fluids are transferred from the hydrosphere to the Earth's mantle through subduction, potentially reaching the Earth's Transition Zone (410-660 km) and even the Earth's lower mantle. Hydrous magmatism and explosive volcanism return part of these fluids to the hydrosphere and atmosphere. To constrain
Tackling tuberculosis: Single-cell approaches to unravel mycobacterial individuality and persistence – MycoINDepth
Diversity is as essential to life as balance. Isogenic populations are inherently heterogeneous, and cell-to-cell variation is predicted to benefit the population as a whole under hostile conditions. The ability of microbes to sense their milieu and promptly adapt is of paramount importance particul
The Arctic is an extremely sensitive region threatened by major and increasing pollution risks. Among them, mercury (Hg), which can have high impacts on organisms and populations, has raised major environmental concerns. These concerns are especially high as Hg levels are substantial and should cont
p-adic Langlands Programme and p-adic Banach Representations – ProBaRe
This project aims to investigate the p-adic Langlands Program, where p is a prime number. The ultimate goal of this program is to establish a correspondence between certain p-adic Banach space representations of some p-adic reductive groups and certain p-adic representations of the absolute Galois g