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Catalases (CAT) and superoxide dismutases (SOD) are antioxidant metalloenzymes necessary for life in oxygen-metabolizing cells to regulate reactive oxygen species (ROS) levels. CAT and SOD take advantages of the redox properties of the metal ion involved in their active site to accelerate the conver

The cost-effective and energetically efficient production of NH3 from N2 or the catalytic reversible transformation of the couple H+/H2 for fuel cell applications are major societal issues that strongly rely on fundamental research. In this project, we want to address these fundamental issues (TRL1)

The aim of the present proposal is to rationally design new boron-centered photo-initiating systems for a sustainable photopolymerization. In collaboration with an industrial partner, the polymerization of monomers, including those issued from renewable sources, will be achieved using visible light

Polycyclic aromatic hydrocarbons (PAHs) consisting of several fused benzene rings are found as products of the incomplete combustion of hydrocarbons (e.g. forest fire) as well as in flowback and produced water from Coal bed methane (CBM) and shale gas extraction process. These two processes are wide

Continuous processes based on Structured Catalytic Supports (SCS) are widely used in industry. Indeed this type of support allows an important surface over volume ratio, a small pressure loss, efficient mass transfers, an intimate mixing of the reagents, and an easy separation of the products from t

Worldwide growth of the global mobility of people and merchandises, along with industrial activity have resulted in a severe increase in airborne pollutants concentration in the last decades. The production of cleaner fuels used for on-road and off-road transportations has been imposed to refiners a

In contrast with other transition metals, gold was long considered inappropriate for catalytic transformations involving redox process. Three main objectives have been envisioned: (i) the development of direct arylation of arenes via Au(I)/Au(III) redox catalytic cycles; (ii) the synthesis of well-d

The steady expansion of glycoscience, the field exploring the structures and functions of carbohydrates, provides many opportunities and challenges for chemists in the ?eld of synthetic oligosaccharide and glycoconjugate research. Within carbohydrate chemistry there is arguably no reaction more impo

This project would take advantage of a pseudo-rotaxane catalyst-polymer assembly to achieve the processivity while sequentiality would be ensured by an original ratchet mechanism allowing unidirectional slippage of the catalyst along the polymer chain; the writing control will be achieved by alloste

The interest in organometallic complexes for optical applications such as luminescent materials, photosensitizers, photocatalysts, biomaterials or nanomaterials for optoelectronics is growing continuously. The development of such applications implies the careful design of metal complexes with appr

The objective of this proposal is to develop original and cheap photosensitive systems capable of generating a very strong reductive power upon illumination, which could be further used in various photochemical reactions or reduction catalysts activation. Reductive quenching (RQ) is particularly rel

The use of renewable resources is essential for a sustainable society. Developing clean catalytic processes to produce value-added chemicals from renewable materials such as wood or plants has become a major goal for chemists. The bio-feedstocks issued from lignocellulose after either enzymatic ferm

To develop their industrial capability in a sustainable way, the European countries have to invest in new production methods and tools. A breakthrough in chemical production could be achieved by adapting technologies for the production of key chemicals to new markets using Process Intensification (P

Over the last years, gold catalysis has gained considerable significance in organic synthesis, since it comprises atom-economic and highly efficient processes for the transformation of relatively simple substrates into valuable, highly complex molecular architectures. Despite these outstanding advan

General context: Cellulose is a natural polymer of beta-D-glucopyranose covalently linked through beta-1,4 linkages. Cellulose is naturally produced in large scale by living organisms and is used since a long time for the production of fibers or paper. Its polysaccharide structure confers to cellulo

SUMMARY AND ADEQUATION TO THE CALL The present program is a fundamental research project aimed at developing innovative catalytic tools for specifically addressing at short- and mid-term, respectively, two contemporary synthetic industrial challenges: i) the regioselectivity limitations of met

Organic electronics is the next ubiquitous platform for the electronics revolution, with devices such as organic light-emitting diodes, which are already entering the market, and many other applications are being envisioned such as, foldable displays, e-paper or radio frequency identification tags,

Many probes have been criticized and discarded due to unreliable results, detection artefacts and/or poor reproducibility. For the last decade hydroethidine (HE) has been shown to be a promising probe for the fluorescent detection of O2•–. Unfortunately, the use of HE in biological systems is limi

The scientific challenges and key questions that will be addressed through the work program can be summarized as follows: 1. Identification of the set of conditions and material properties which lead to surface or intramembrane crystallization for the model system BaCO3 ; 2. Is it possible to quan

Metal complexes are widely used nowadays to treat numerous pathologies (cancer, rheumatoid arthritis, osteoporosis, etc.). However, despite their daily clinical use, their mechanisms of action are still poorly understood. An interesting strategy for elucidating them consists in grafting a probe onto

The activation of thermally stable small molecules is one of the central tasks in catalysis and modern synthetic chemistry, which is closely related to some important issues for our society such as hydrogen economy or carbon dioxide conversion into organic materials. Such processes require new catal

Photopolymerization is a well-established technology showing a growing interest because of significant economical and environmental advantages. Nevertheless, more than 95% of films and coatings derived wherefrom are based on a radical process strongly inhibited by atmospheric oxygen. There is thus a

Ligands synthesis and their coordination studies with several cationic metals are responsible of spectacular advances in medical diagnostic and therapy. Among the various studied chelators, polyazacycloalkanes have proved to be more efficient in almost all imaging modalities and therapy methodologie

Organic chemists are still faced with important challenges, especially with regard to the efficient preparation of enantiopure molecules. In modern organic chemistry, organometallic catalysis is one of the main methods employed to obtain these compounds. Nevertheless, the applications of enantiosele

The HEL-NHC project involves three complementary research groups: 1) “Phosphorus and Molecular Materials” (PMM); 2) “Nanocatalysis and Molecular Catalysis for Fine Chemistry” (NMCFC) (both are belonging to the “Organometallics: Materials & Catalysis” team of the “Institut des sciences chimiques de R

Iron catalysts are an inexpensive and non-toxic alternative to the noble-metal-based systems used in organometallic catalysis. This is particularly true in the field of C—C bond formation by cross-coupling reactions, which is mainly dominated by palladium catalysis. The incredible breakthrough which

OMaChem - Organocatalytic Meldrum’s acid Chemistry – aims at studying original organocatalyzed synthetic methodologies towards the construction of bio-relevant chiral heterocycles making use of novels/underexplored chemical reactivity of Meldrum’s acid derivatives; cheap ( < 0.8 €/g), storable, safe

Mechanochemistry is an important tool for organic chemistry, allowing to reduce environmental impact of reactions by reducing the quantities of solvent used, enhancing reaction rates and sometimes giving rise to unattainable compounds in solution. Additionally, grinding using ball-mill is a scalable

Catalysis is the essential technology for precisely transforming the chemical structure of matter on a large scale. It lies at the heart of our quality of life, and it is also essential to a healthy economy. One of the main challenges for catalysis in the 21st century is to better understand and the

The GeDEmi project is devoted to the rationalization and optimization of molecules presenting a dual emission based on the Excited State Intramolecular Proton Transfer mechanism. These fluorescent molecules present a strong H-bond and, after photon absorption, a prototropy occurs from the excited en

The bioorthogonal and click chemistry toolbox provides a set of reliable chemical reactions enabling the chemoselective covalent bond formation between two chemical entities without interfering with other existing (bio)functionalities. In the space of a decade, these transformations have dramaticall

Heterogeneous catalysis of nanomaterials has emerged as an efficient way to speed up the catalytic process due to the higher surface area of nanoparticles compared to their bulk counterparts. A challenging issue is the development of heterogeneous catalysis with a high selectivity close to 100% as w

BORON HAT-TRICK project is centered on fundamental research and addresses the conception and the study of new boron-based objects and their reactivity as catalysts in racemic then enantioselective transformations. The main aim of this proposal is to generate rapidly new tools for asymmetric syntheti