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Ugly duckling feature for melanoma detection : a validation study – DIAMELA
Most of the melanomas are recognizable from their visual characteristics, especially significant when they differ from those of the other nevi of the individual observed (ugly duckling). Rarely described in the literature, this idea is tested and evaluated for impact.
Ontology Research, Image Features, Letterform Analysis on Multilingual Medieval Scripts – ORIFLAMMS
The ORIFLAMMS project (Ontology Research, Image Features, Letterform Analysis on Multilingual Medieval
Megathrust earthquakes in Chile: The 2010 Maule Earthquake (Mw 8.8) and sismo-tectonic implications – MEGA-Chile
produced moderate strong motion. Is this a unique feature of this event, or is it typical of most large [...] contain any events larger than Mw 7.1, a puzzling feature indeed. We dispose of a long series of aftershock [...] has long standing segments associated both with features of the oceanic plate (seamounts, ridges) and of
Genetic sex determination and evolution of sexual dimorphism in seaweeds – SEXSEAWEED
Sex chromosomes have evolved independently in a broad range of eukaryotes. The structure, function and evolution of sex determining regions have been studied in animals, plants and fungi, but we know very little about how sex is determined in other eukaryotic lineages. The SEXSEAWEED project studies the evolution of sex determination in the brown algae, a group that has been evolving independently from animals and plants for more than a billion years.
Origin, adaptation and evolution of Plasmodium falciparum – ORIGIN
Some very recent studies claimed that P. falciparum appeared in humans in Africa following a recent transfer from gorillas. Although the data presented in these studies were quite conclusive, it still remains possible that other primate species might have served as sources. In addition, the modalities and the consequences of this transfer on the evolution of the parasite are still unknown.
CD28 antagonists in autoimmune renal diseases – CAARD
or worsening of proteinuria, on renal pathology features (inflammation, necrosis, immune deposits), on [...] mice immunized with MPO and who develop renal features similar to those noted in human AAV. The efficiency [...] antagonist will be assessed based on renal pathology features (inflammation, necrosis), and on the analysis
Robustness to inducer dose and evolution of the vulva signaling network in Caenorhabditis and Oscheius nematodes – NETWORM
been made in the vulva system. A key quantitative feature of the system thus remains unaddressed: how robust [...] systemic and evolutionary approaches is a key feature of the present proposal. The vulva network as known [...] framework, has allowed to infer evolution in some features of the intercellular signaling system, despite
Sensory Motor Integration in the Cerebello-Cortical System – SMIC
Motor plans in the brain are continuously updated by incoming sensory information. This process of sensorymotor integration is still poorly understood. The present project aims at unraveling how incoming sensory<br />information is filtered and fed in the motor cortex. For this purpose we focus on two major afferent structures of the motor cortex which form functional loops with this cortical area: the primary sensory cortex and the cerebellum.
Synthesis and Cellular Evaluation of Specific Porphyrin and Salen Based G-Quadruplex Ligands – QUARPDIEMS
In vitro, single-stranded G-rich nucleic acid sequences can adopt a particular conformation called a G-quadruplex. The main objectives of this project are the design, the synthesis and the biophysical and cellular characterization of porphyrin and salen-based G-quadruplex ligands selective for particular G-quadruplex structures
ECONOMICS AND SOCIETY – ECOSOC
and the legal and regulatory system. The main feature of our approach is to treat these issues as a single