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Integrated IR sensor based on SEIRA effect for an efficient detection use of low concentration chemical and biological species – LOUISE
In a context of growing demand for integrated sensors for environmental and biological applications, the objective of the LOUISE project is to design and evaluate a micro-sensor for the implementation of infrared spectroscopy amplified by surface plasmonic effects.
New titanium alloys with a combination of high strength, strain hardening and high ductility, induced by TRIP and TWIP effects – TITWIP
The TITWIP project is focused on the development of a new family of titanium-based materials capable of transforming under the effect of deformation, either by phase transformation or by mechanical twinning. This feature gives them a high mechanical strength combined with a strong strain-hardening and a high ductility.
Alcoholic and Non-Alcoholic fatty liver disease (ALD, NAFLD) are leading causes of liver-related morbi-mortality and co-morbidities are emerging as factors accelerating disease progression. Studies of the interplay between obesity and alcohol on the severity and progression of liver lesions and identification of targets with therapeutic potential constitute a major issue.
The 3D organization of the genome is an important control mechanism of genomic function. <br /> <br />Our recent data unveiled that chromosomes adopt distinct organizations according to the metabolic status of the cell. In particular, long-lived quiescent cells cells group their telomeres into a hypercluster, reshaping the genome architecture into a conformation that may contribute to maintain longevity of <br />quiescent cells (Guidi et al, 2015).
Basal body anchoring in ciliogenesis: structure-function analysis
Multi-luminescent up-converting nanohybrids with controlled blinking for super-resolution imaging and single particle tracking – BLINK
Crowned by the 2014 Nobel Prize, new non-invasive, far-field super-resolution microscopies classically rely on the excitation of fluorescent probes with a high energy light. The aim of the Blink project is to exploit the “upconversion” phenomenenon, a non linear process that converts near infra red light into visible ones in a non coherent way.
The ribosome is a giant ribonucleoprotein cellular assembly that translates genetic code into protein in living cells. The overall goal of our research is to understand how the atomic structure of the ribosome ultimately determines its function. As the ribosome is main target of antibiotics, the study of ribosome is important not only for the fundamental knowledge, but also for developing new therapeutic, which will target the ribosome.
A 3D study of the plasticity in deformed polycrystals based on diffraction experiments and crystal-plasticity simulations – 3DPLASTICITY
Strain localization in deformed polycrystalline materials is of major importance for a large number of physical phenomena occurring during the lifetime of a material, such as fatigue, rupture or corrosion cracking. The early state of plastic deformation of a material is of strong interest on the one hand because it is encountered during severe loading conditions, and on the other hand because particularly strong strain heterogeneities occur, as only some grains deform plastically.
One of the great challenges in the development of small protein drugs is the introduction of modifications which allow to increase the stability of the protein, its half-life in biological fluids and the yield of production. Contrary to short peptides, the cyclization of large polypeptides or proteins is still in its infancy. The goal of the project is to facilitate the access to these molecules for applications in regenerative medicine.
The overall objective of this proposal is to better understand the physiopathogeny of PADs associated with hyper-activation of PI3K/AKT/mTOR signalling, to analyze the impact of “hyper-activated” PI3K signalling on gene expression, lymphocyte function and differentiation and to identify novel molecular causes.