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Identification of novel inhibitors against emerging human coronaviruses SARS-CoV and MERS-CoV from host cellular transcriptionic signatures – CoV-SigN
In 2012, a novel human coronavirus (MERS-CoV) was identified in the Middle East as the causative agent [...] and community clusters. Emergence of this new coronavirus in humans raises concerns about a possible widespread [...] required to fight against these emerging hazardous coronaviruses adequately. In this context, the main objective
Identifying SARS-CoV-2-like and other coronaviruses able to infect humans in bats from Indochina peninsula – BAT-CoV-ASIA
objective of the project is to identify bat coronaviruses close to SARS-CoV-2 and other alpha and bet
Immune response during Covid19 infection – CovImmune
Europe has been facing the outbreak of the new coronavirus disease 2019 (COVID-19). This highly contagious [...] zoonosis caused by a virus SARS-CoV-2 from the coronavirus family that emerged in Wuhan in Chine in November
Immunostimulating molecules with a broad-spectrum antiviral activity: a proof of concept in non-human primate models – STING-2.0
measles virus, human parainfluenza virus 3, coronavirus 229E) for which there is no treatment available
Implementation of a fast and reliable assay for the high-throughput screening of antiviral molecules active against SARS-CoV-2 – Alpha-COV
Syndrome Coronavirus 2 (SARS-CoV-2) has led to an unprecedented pandemic termed Covid-19 (Coronavirus disease
Inborn errors of immunity underlying life-threatening COVID-19 in previously healthy patients – GENCOVID
In December 2019, a pneumonia due to a novel coronavirus (SARS-CoV-2) emerged in the city of Wuhan, China [...] ranging from asymptomatic infection to lethal coronavirus infectious disease-19 (COVID-19). Two groups
Inhibition of SARS-Cov2-S - ACE2 interaction AS A THERAPEUTIC TARGET – ACE2-S-Cov
Coronavirus disease 2019 (COVID-19), which is caused by the recently discovered severe acute respiratory [...] respiratory syndrome coronavirus 2 (SARS-CoV-2), has become pandemic, in the absence of an approved drug treatment [...] virus surface spike protein (S), which mediates coronavirus entry into the cell, is an attractive target
Inhibition of coronaviruses infections using innovative nanostructures – NanoMERS
The main goal of the NanoMERS project is the identification of specific and efficient nanomaterials derived anti-MERS-CoV agents effectively inhibiting viral entry and their in vitro and in vivo testing. The focusis on the use of carbon based nanostructures, notably modified C-dots and graphene-dots and nanoparticle formulations of poly(D, L-lactide-co-glycolide) (PLGA).
Interventions for Covid-19 infection: a living mapping of research and a series of living network meta-analyses – living-NMA-covid
Context: In December 2019, a novel coronavirus outbreak was documented in Wuhan, Hubei Province, China [...] first 6 weeks of the new decade, this novel coronavirus, known as SARS-CoV-2, has spread from China to
Involvement of circulating fibrocytes in pathophysiology and prognosis of COVID-19 pneumonia – FIBROCO
High circulating levels of fibrocytes are correlated to an unfavourable outcome during acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis. COVID-19 pneumonia shares common histological and inflammatory features with ARDS. We aimed to determine the involvement of circulating fibrocytes during the course of COVID-19 pneumonia, and to assess if fibrocytes could be a prognosis biomarker.
