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Engineering nanobinders to block SARS-CoV-2 entry – SARS2BlockEntry
The novel coronavirus SARS-CoV-2 has recently emerged as a human pathogen in China’s Hubei province, causing severe respiratory illness and pneumonia. According to the World Health Organization (WHO) on March 17th, 2020, there have been over 180,000 cases globally, leading to at least 7,500 deaths.
Fe-S clusters as essential cofactor of Coronavirus replication – CoV-FeS
Replicating and maintaining genome integrity is an upmost task for all organisms. To replicate their exceptionally large genome, Coronaviruses (CoVs) employ a unique and sophisticated RNA-synthesis and correction machinery, composed of, at least, the RNA-dependent RNA polymerase (RdRp, nsp12), the h
Functional Interrogation of SARS-CoV-2 RNA-Host Binding Proteins in viral replication – FISHBP
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19 pandemic, which over a span of few month, has caused a devastating global health crisis. In absence of antiviral therapies or approved vaccine, there is an urgent need to understand the molecular interact
Genome-wide CRISPR screens for drug target identification and inhibition of SARS-CoV-2 replication – CRISPR-TARGET-CoV
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the current coronavirus disease 2019 (COVID-19) pandemic. This virus emerged in China at the end of 2019 and has, since then, dramatically spread across the world. As of today (18th of June 2020), SARS-CoV-2 has
Household transmission investigation study for SARS-CoV-2 in French Guiana – EPI-COVID-19
Since December 2019, a new coronavirus, SARS-CoV-2, has been identified in the city of Wuhan in China. By 22 March 2020, the virus had spread to all continents, causing 294 110 confirmed cases and 12 944 deaths worldwide. The detection and spread of this emerging respiratory pathogen are accompanied
Human colonic organoids as a model to study SARS-CoV-2 variants infection – Organovir
Our proposal aims to monitor the ability of SARS-CoV-2 variants of concern, including South Africa, United Kingdom and Brazil ones, to infect human colonic organoid-derived cell monolayers, a model of choice to study host pathogen interaction in a standardized and reproducible way closely mimicking
Human intestine biomimetic model to test the impact of microbiota products during SARS-CoV-2 infection – COVIDMicroGutModel
In this project we propose a human Intestinal model combining human primary cells (organoid derived) from colonic and small intestinal tissues with organ-on-chip technology to recapitulate the full hallmark of the small intestinal and colonic barrier (cells diversity, 3D topology, mechanical stimula
Identification of SARS-CoV-2 RNA ibinding proteins durig viral replication – CoV-2RBP
The beginning of 2020 has seen the emergence of COVID-19 pandemic, a respiratory disease caused by a novel coronavirus (CoV), the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In the absence of efficient cure or vaccine currently available, there is an imminent need to better underst
Identification of SARS-Cov-2 neutralizing Affitins – COVAFFIT
The emergence in 2019 of a new severe acute respiratory syndrome coronavirus (SARS-CoV-2) has led to a global pandemic with nearly 31 million infected people of whom nearly 1 million have died. This virus is particularly contagious and uses the S protein (or spike protein) through its RBD domain to
Identification of early biomarkers of the response to corticosteroid therapy in COVID-19 patients. – CortiCoV
SARS-CoV-2 is the human coronavirus that caused the pandemic that began in Wuhan, China at the end of 2019. This virus is the source of a contagious respiratory pathology known as COVID-19. The study of the first patients infected with severe forms of COVID-19 revealed an intense inflammatory respon
