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Development and characterization of electronic noses for the rapid detection of COVID-19 in exhaled breath – COVINose
Early, easy and rapid diagnosis of coronavirus disease 2019 (COVID-19) is of the utmost importance but remains challenging. Breath analysis is an innovative, non-invasive, real-time, point-of-care technique for detecting volatile organic compounds (VOCs) in expired breath with potential for use in d
Development of RNA aptamers targeting the NADPH oxidase DUOX1 as a therapeutic approach to treat lung fibrosis – APFIBROX
Chronic respiratory diseases, including lung fibrosis are a major and increasing burden in terms of morbidity and mortality. Lung fibrosis is characterized by excessive matrix deposition leading to destruction of lung architecture and ultimately fatal impairment of lung function. Idiopathic pulmonar
Development of SARS-CoV-2 vaccines – DC-CoVaC
Résumé: SARS-CoV-2 is a betacoronavirus that has recently emerged as a human pathogen in the city of Wuhan in China’s Hubei province. The disease caused by this newly identified virus has been named COVID-19 and symptoms include fever, severe respiratory illness and pneumonia. As of March 2020, the
Development of Succinate-based analogues and formulations against SARS-CoV-2 and influenza viruses-induced respiratory infections – SuccesS
The emergence of pandemic respiratory viruses is a major concern. Those viruses include coronaviruses such as SARS-CoV-2 and influenza A viruses (IAV). There are currently no efficient drugs against coronaviruses and the efficacy of anti-IAV drugs is disputed. Vaccination should constitute the most
Development of embryonic lymphoid cells that shape the thymic architecture – DELSTAR
The thymus provides the environment for the development and selection of T cells. Thymic epithelial cells coordinate virtually all stages of T cell development, providing key cytokines, chemokines and ligands for the commitment, survival and proliferation of thymocytes and also for positive and nega
Early identification of risk associated with drugs used in COVID-19: analysis of global pharmacovigilance data – Vigi-Drugs COVID-19
This project aims to investigate and characterise early the major adverse drug reactions of drugs used and/or approved for the treatment of patients with Covid19. The analyses are based on the WHO global pharmacovigilance database: VigiBase® containing more than 27 million adverse drug reactions,
Ecoepidemiology of coronaviruses, from wildlife to the human population, and assessment of the emerging potential – EPICOREM
More than 60% of infectious diseases in humans are caused by pathogens likewise circulating in domestic animals and wildlife. Most of these pathogens are viruses whose genome is an RNA molecule. RNA viruses are characterized by their genetic diversity, a population structure in quasispecies, a high
Emergence dynamics of Sarbecovirus coronaviruses : Zoonose mecanisms. – EmerCoV
The 21st century began with a wave of emerging epidemic infectious diseases, of which COVID-19 is considered one of the most serious, with a devastating impact worldwide. Seventeen years after the emergence of SARS-CoV from 2002-2003, in 2019, it is again a Betacoronavirus Sarbecovirus (SARS-CoV2, t
Emerging SARS-CoV-2 variants: intersection of entry routes and antiviral responses – VERSATILE
The rapid emergence of numerous SARS-CoV-2 variants poses a global threat to human health and undermines the goal of achieving herd immunity through vaccination. The overarching aim of VERSATILE is to understand the interplay between cell entry routes and host antiviral responses. This will be addre
Endothelial damage and repair in SARS-CoV-2 related vascular injury – ENDOCOV-19
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and can present with a range of manifestations. SARS-CoV-2 infects type II pneumocytes by binding to membrane-bound angiotensin-converting enzyme 2 (ACE2). Rapidly after the outbreak, re
