Search for a funded project
Characterization of the microVAScular dysfunction in COvid-19 ARDS. – VASCO
To establish the prognostic value of the alveolar-dead space (measured iteratively) in patients with COVID-19 and non-COVID-19 ARDS. Establish the respective influences of the biological parameters of endothelial damage, of the biological parameters of coagulopathy, of the parameters set on the art
Characterization of the role of betacoronavirus M protein in viral assembly – coronem
Coronaviruses are positive-stranded RNA, enveloped viruses. The lipidic envelope contains 3 viral proteins with the membrane protein (M) being the most abundant component and the driving force in viral assembly. The main objective of this project is to better understand the morphogenesis of MERS-CoV
Clinical proteomic characterization of the SARS-CoV-2 Spike protein to optimize its detection and the development of serological assays – proteoCOVID
Following the emergence and global spread of a new coronavirus called SARS-CoV-2, there is an urgent need to explore various aspects of this new disease, including its mode of transmission, virus-host interactions and immune response, diagnosis and therapy. This collaborative project leverages the c
Collaborative Economy Platform Agents’ Status in the light of SOcial Citizenship – CEPASSOC
The project started from observing the rise of collaborative economy and digital platforms. They are new intermediaries between consumers and providers. These providers or agents have diverse statuses (independent workers, employees…) which are just starting to be regulated by States. It is these re
Comprehension of MAIT cell functions during COVID-19 – COMAIT-19
Dysregulated host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the lung can lead to life-threatening acute respiratory distress syndrome (ARDS). The molecular and cellular host factors implicated in this uncontrolled inflammatory response recently emerged. Howev
Coronavirus Diagnostic combined with seasonal Flu Sensing – CorDial-FLU
Worldwide, infections and death from SARS-CoV-2 continue despite lockdown and the use of masks. What started as a temporary sanitary issue, has morphed into a more permanent and long-lasting pan epidemic outbreak. One efficient manner to limit COVID-19 spreading and an adequate means of better manag
Coronavirus membrane pores – MemPoco
Coronaviral infection involves remodelling of the host endoplasmic reticulum (ER) to form double membrane vesicles (DMVs); compartments that house the viral replication complexes and RNA. A recent study identified a transmembrane pore that crosses both membranes of the DMV, providing a point of exch
Covid-19 protein-protein interaction mapping – Cov2PIM
The identification of virus-virus and virus-host protein-protein interactions is a determinant element for the understanding of the mechanisms of replication and viral transmission. The knowledge of the molecular details of these protein interactions is a prerequisite for the discovery of new therap
Determinants of SARS-CoV-2 infectivity in a cohort of children and their parents. – PED-COVID_Infect
COVID-19 represents an unprecedented world-wide challenge due to the transmissibility of the virus, its impact on morbidity and mortality, the uncertainty regarding the development of long-term immunity, and the current paucity of efficient therapeutic options. Understanding the kinetics of shedding
Developing a new viro-fluidic technology to explore the viral production from infected cells in real-time at the single-cell and single-particle levels – virofluidics
The goal of this interdisciplinary project is to combine virology to the powerful nano/microfluidic strategies (we called "viro-fluidics") to study, for the first time, the viral egress dynamics at the scales of living single-cells and single-viral nanoparticles. Viro-fluidics will be adapted to stu
