Search for a funded project
Propagation of an amyloid fold as a mean of signal transmission between a STAND protein and a prion – STANDPRION
amyloid folds in signal transduction
A humanised mouse expressing a human class I and class II HLA gene and the human insulin gene as a preclinical model for human type 1 diabetes. – YES
in particular HLA-A*0201. Among ß-cell autoantigens, insulin has been ascribed a key role in T1D. While [...] (hPPI), HLA-A*0201, DQ8 transgenes and lacking their mouse counterparts, 2) evaluate YES mice as a new preclinical [...] strategies to induce immune tolerance to hPPI as a therapy in T1D. Methodology. We have obtained YES
Developmental, behavioral, cellular and molecular evaluation of a embryo-fetal and juvenile toxicity induced by the chronic exposure during gestational and lactational phases to a mixture of the 6 NDL-PCB indicators in a mouse model – NEURODEVETOX
the study, with a real food matrice whom degree of contamination directly results from a real environmental [...] The raise of anthropogenic activities has led to a large release of various chemicals in the environment [...] contamination. Actually, epidemiological studies reveal a significant raise of mental and neurological disorders
Establishment of innovative and proprietary methods for the manufacturing and quality control testing of a clinical grade gene therapy vector for the treatment of patients affected with a pigmented retinopathy secondary to a mutation in the pde6ß gene – PDE6-ß
Establishment of innovative and proprietary methods for the manufacturing and quality control testing of a clinical grade gene therapy vector for the treatment of patients affected with a pigmented retinopathy secondary to a mutation in the phosphodiesterase 6ß gene (pde6-ß)
Immunostimulating molecules with a broad-spectrum antiviral activity: a proof of concept in non-human primate models – STING-2.0
cted patients is extremely limited, and there is a critical need for broad-spectrum antiviral molecules [...] at Institut Pasteur (CNRS URA3015) has developed a high-throughput functional assay to monitor the activation [...] antiviral genes in human cells (US patent N°12/648225; “A mammalian cell-based screening assay to identify antiviral
Molecular assembly of the pneumococcal pilus . From a natural to a biotechnological toolbox – PILIPATH
Antibiotics inhibit essential physiological processes in bacteria, which consequently develop mecanisms to escape to antibiotics action. To reduce and/or delay the emergence of resistant strains, strategies to design new anti-bacterial drugs aim to target important steps in the disease physiopathology.
Effects of increasing aridity and drought frequency on a biodiversity dependent savanna socio-ecological systems: scenarios for a surface water driven protected area and its periphery – SAVARID
experience and a long working experience in African savanna. These attributes thus offer a good feasibility [...] objective here is to predict possible trajectories of a biodiversity-based socio-ecological system (protected [...] systems may create the conditions for promoting a new integrated land-use system based on sustainable
Structural and functional relationships between the NS5A and NS5B Hepatitis C Virus proteins and the host Cyclophilin A. – StruFunc5A5B
The viral NS5A and NS5B proteins as well as the human protein CypA are required for hepatitis C virus (HCV) replication. Their interactions thus represent potential therapeutic targets.
Theoretical and experimental study of a trithermal system with a new thermal compression process of the working fluid, for the residential heating or combined heat and power market. – TRICOM
electricity to realize a thermal compression. This technology incorporates a completely original multistage [...] research program is firstly Experimental Development of a new concept of thermal heat pump for residential heating [...] Industrial Research leading to the definition of a micro-cogeneration boiler of second generation.
A parasite enzyme as a new therapeutic agent in Inflammatory Bowel Diseases – ACROHNEM
Molecule) aims at the development of a well- characterized parasite protein as a new therapeutic agent in dramatically [...] increasing Inflammatory Bowel Diseases (IBD), with a particular focus on childhood onset Crohn’ s disease(CD) [...] our environment. The absence of parasitic worms, a situation seen in industrialized world, or the intensive