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Pathophysiologic role of HDAC6 overexpression consecutive to a mutation abrogating a miRNA-mediated post-transcriptional regulation in a X-linked chondrodysplasia. – CHONDRO-X
We work on a new form of familial X-linked dominant chondrodysplasia (Chassaing et al, 2005). The phenotype [...] and moderate mental retardation. We have identified a mutation in the 3’UTR of the deacetylase HDAC6 gene [...] that this mutation abrogates the interaction of a specific micro-RNA (miRNA) with this 3’ untranslated
A technological breakthrough for the development of a new, more innocuous PVDC with enhanced properties – ASAP
the development of a new generation of PVDC. In order to reach that goal, there is a high need for tec [...] some limitations: migration of additives, which is a common problem to all industrial polymers synthesized [...] (such as by-products). This understanding requires a preliminary analysis of the co-extruded and coated
A new paradigm in numerical simulation – Separated variables decomposition for a priori model reduction – SIM-DREAM
expressing such a solution. The partners of this project (P. Ladeveze, F. Chinesta, A. Ammar and A. Nouy) [...] optimal when constructed “a posteriori”, being only approximated when constructed “a priori”. Obviously, [...] Nouy) proposed some years ago a novel efficient technique able to circumvent the challenging issues just described
Cellular, molecular and systems-level mechanisms underlying the establishment of a brain cognitive reserve in a mouse model of Alzheimer’s disease – CoRehAlz
and for a time-restricted period to enable long-lasting cerebral modifications in the form of a “cognitive [...] interdependent tasks, will benefit from a consortium of 3 partners with a high level of complementary expertise [...] exposure to environmental enrichment (EE) used as a rehabilitative therapy in rodents. Building upon these
Preclinical study of a new innovative peptide therapy for a causative treatment of sepsis – LR17 peptide therapy in sepsis
Sepsis exemplifies a complex clinical syndrome that results from a harmful and damaging host response [...] , etc), acting like a decoy receptor and competing against TREM-1 receptor. As a result of this activity [...] (TREM-1). Indeed, TREM-1 and TLRs appear to cooperate in a synergistic way. The role of TREM-1 as an amplifier
Innovative solution allowing to detect and characterize progress over time of a skin cancer, using a standardized methodology and equipment, for the use of specialized and general physicians. – MELASCAN
the IR by means of a standardized device and a methodology. The integration of a multi-spectral light [...] these data within a cummunity base certified by a group of experts will allow to end in a decision-making [...] the skin with a tool eliminating the reflections of the stratum corneum and allowing a significant m
Study of a numerical and physical model of a human ballistic test dummy head for the reconstruction of crime scene. – SUBSTITETE
coupled with a numerical study of the proposed structure. A numerical dummy head would provide a powerful [...] The simultaneous development of a physical and a numerical model is a strong scientific choice. We believe [...] propose here to study and design simultaneously a materiel and a numerical model of the human head for ballistics
Crossed Histories : a literary history of sciences and a scientific history of literature during the nineteenth century (Europe and United States – HC19
Crossed Histories in the nineteenth century : the history of literature from a scientific point of view and the history of science from a literary point of view
Early abnormalities in a mouse model for myotonic dystrophy : a model for Congenital Myotonic Dystrophy ? – MODELCDM
the CDM form of the disease remains a mystery. We have created a transgenic mouse model to study the [...] Myotonic dystrophy type I (DM1) is a dominantly inherited disorder with an incidence of 1 in 8000 adults [...] sucking and swallowing, facial weakness and later on by a delayed motor development and mental retardation.
Conception of new surfaces with antibacterial properties by a multidisciplinary and a multiscale approach – SANBACT
procedures generating a significant amount of effluent. Consequently, this project exhibits a threefold interest: [...] essential in a process of rational and effective control of surface biocontamination. Result of a federative [...] bactericidal properties, bacteriostatical properties or a "slow down growth” effect. All these properties and