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Towards clinical investigation on the use of Mineralocorticoid Receptor Antagonist for wet Age-Related Macular Degeneration
Wet AMD remains a major cause of vision loss despite anti-VEGF therapy due to frequent re-injections, geographic atrophy, fibrosis and no effects on neovessel growth. Based on pre clinical results and pilote clinical study, we propose an alternative therapy using antagonism of mineralocorticoid receptors (MRA).<br />MR-A-MD aims at developing a local formulation of spironolactone and identifying molecular and imaging markers to optimize the design of a prospective randomized clinical trial.
Towards a comprehensive model of plant plasma membrane lipid bilayer
Towards a comprehensive model of plant plasma membrane lipid bilayer
Towards a Unified theory of biotic Interactions: the roLe of environmental
en 2022 après les années de transition 2020 et 2021. Recherche : Le LabEx contribue
Towards Ligand-Induced Fluorescent Proteins
The UnaG protein emits intense and bright green light once the bilirubin (BR) ligand is bound to the protein. BR is an indirect marker of various human liver functions UnaG is therefore a promising direct medical tool to track liver disease as well as a probe to detect cardiovascular diseases. The project aims to model this new class to understand its electronic, spectral, and conformational properties as well as to design new ligands or mutants enlarging the possible applications.
Towards Industrialisation of Direct Liquid Injection CVD Process for Alkaline Niobate Thin Films
Towards Industrialisation of Direct Liquid Injection CVD Process for Alkaline Niobate Thin Films
Toward a multi-stakeholder socio-seismological observation network for seismic risk reduction in Haiti
builds on the S2RHAI pilot project (CNRS/IRD, 2019-2021), which used low-cost and low-maintenance seismological
Toward Non-Invasive Ultrasound Surgery
Only 25% of patients with primary or secondary liver tumors are candidates for curative treatment. Focused ultrasound has the potential to be a new therapeutic option but major innovations are needed. The challenge of the TONUS project is to implement these breakthrough innovations and to demonstrate the feasibility, efficacy and preclinical safety of this new treatment in order to be able to start using it in clinically.
Toulouse Graduate School défis en économie et sciences sociales quantitatives
successful multi-disciplinary Summer School since 2021 organized by IAST and launch of two new multi-d [...] debates as well as the Common Good Summit since 2021; (14) new research partnerships and successful
Topological IV-VI semiconductor heterostructures: A platform to study topological phase transitions and strain sensitive topology
The central objective of this project is to resolve the technological challenges for the realization of topological heterostructures and answer the question of how the topological interface states can be tuned and controlled by external means.
To capitalize on activated adventitial fibroblasts metabolism to treat pulmonary hypertension
Pulmonary hypertension (PH) is a deadly enigmatic disease of the pulmonary vasculature that is becoming increasingly prevalent worldwide with substantial unmet medical needs. In response to hormonal, inflammatory and environmental stresses such as hypoxia/ischemia, or vascular distention, pulmonary artery adventitial fibroblasts (PAAF) are the first vascular wall cells to exhibit evidence of activation.
