CE20 - Biologie des animaux, des organismes photosynthétiques et des micro-organismes

Chassis strain engineering for heterologous production of lipopeptides – HETEROCLIPS

Submission summary

Cyclic lipopeptides (CLiPs) are microbial secondary metabolites with a large structural biodiversity which gives them a multitude of biological activities that can be exploited in various sectors such as human and animal health (antibiotics, antivirals) or plant health (antibiotics, antifungals, defense inducers). They represent a source of active compounds that is still untapped for lack of knowledge on their mechanisms of action and on structure/function relationships. The objective of this project is to develop an innovative technology based on heterologous production and specific integrated production /purification processes to generate a collection of structurally diverse CLiPs. Different activities related to biocontrol will be tested, especially to meet the growing need for alternatives to pesticides.

Project coordination

Valérie LECLERE (UMR 1158 - BioEcoAgro - UMR Transfrontalière BioEcoAgro)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


RIBP Résistance Induite et Bio-protection des Plantes
BEA ULILLE UMR 1158 - BioEcoAgro - UMR Transfrontalière BioEcoAgro
Bioinfo ULille (PLBS) Plateformes Lilloises en Biologie Santé

Help of the ANR 691,424 euros
Beginning and duration of the scientific project: April 2023 - 48 Months

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