CE19 - Technologies pour la santé

Unmasking Thrombo-inflammation by in vivo Molecular Magnetic Resonance Imaging of von Willebrand Factor – FlaMRIng

Submission summary

Thrombo-inflammation has emerged as a key pathophysiologic player in a large number of disorders. It is caused by the activation of endothelial cells in injured tissues, leading to secondary microvascular thrombosis and further tissue damage. To date, available imaging methods only allow to detect the consequences of thrombo-inflammation, such as tissue hypoperfusion and necrosis, preventing prophylactic treatment. Thus, the ability to detect the 1st steps of the thrombo-inflammatory reaction using non-invasive imaging could not only improve our pathophysiological understanding of thrombo-inflammatory disorders but also provide a window for patient therapeutic intervention before irreversible injury occurs. In this project, we propose to develop an original method to image thrombo-inflammation using molecular magnetic resonance imaging (MRI). This method will be characterized in thrombo-inflammatory disorders such as stroke, subarachnoid hemorrhage and systemic inflammatory disorders.

Project coordination

Sara Martinez De Lizarrondo (Physiopathologie et imagerie des maladies neurologiques)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

HITh Hémostase, Inflammation, Thrombose
PHIND Physiopathologie et imagerie des maladies neurologiques

Help of the ANR 415,260 euros
Beginning and duration of the scientific project: - 36 Months

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