CE17 - Recherche translationnelle en santé

Normative and Quantitative Framework for Brain Tissue Damage Characterization at High & Ultra-High Field MRI – NormaBRAIN

Submission summary

Quantitative magnetic resonance imaging (MRI) allows precise characterization of pathophysiological processes in healthy and damaged tissues at the individual level and is a technique of choice in the field of precision medicine. Despite this strong potential and the numerous quantitative biomarkers it provides, quantitative MRI in neurology is not currently established in conventional radiology. Indeed, clinical routine requires short examination times and radiologists must be able to rely on the wide range of images usually acquired (non-quantitative), which, until now, provide a qualitative description of biological tissue properties and their possible pathological damage, and which are used for patient management. The NormaBrain project proposes to address these challenges by meeting the following objectives 1. the standardization of optimized and accelerated quantitative MRI sequences, dedicated to the study of the human brain at high and ultra-high magnetic fields (3T and 7T), and compatible with the time constraints of routine clinical imaging, 2. the generation of normative bases of key parameters in quantitative MRI according to age and sex at high and ultra-high magnetic fields (3T and 7T), 3. The development of integrated image processing tools necessary for the a posteriori reconstruction of conventional images using synthetic MRI, as well as for the generation of statistical maps evaluating for each patient the quantitative MRI biomarkers and their variation with respect to the normal population, and 4. The evaluation in a multisite clinical context of the proposed solution (acquisition, reconstruction, processing). The target application is neurological imaging in the context of multiple sclerosis. The objectives of providing fast and robust quantitative MRI technologies, associated with a fully automated processing and interpretation pipeline, will complement conventional MRI techniques by providing new insights into mechanisms underlying disease progression and therapeutic follow-up. We specifically aim to define quantitative standards to democratize the use of quantitative MRI at an individual level in neurology. At the end of this project, the feasibility of quantitative imaging in a clinical setting and compatible with current radiological practice will be demonstrated and may allow for a larger scale deployment.

Project coordinator

Monsieur Thomas Troalen (SIEMENS HEALTHCARE SAS)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

Siemens HEALTHINEERS SIEMENS HEALTHCARE SAS
DRS-APHM APHM Direction de la Recherche Santé
CRMBM Centre de résonance magnétique biologique et médicale
Pôle Neurosciences Tête & Cou

Help of the ANR 647,036 euros
Beginning and duration of the scientific project: January 2023 - 48 Months

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