CE44 - Biochimie du Vivant

Circuits of modifications in tRNAs: networks enabling dynamic regulation of modifications – CiMoDyMo

Submission summary

Maturation of RNAs involves post-transcriptional chemical modifications of its nucleotides. Among the different RNA families, transfer RNAs (tRNAs) display not only the highest variety of chemical modifications, but also the highest density of modification per transcript. While a simple model would be that modifications are introduced to tRNA independently, several modification circuits have been identified in which one or more modifications stimulate or negatively regulate the formation of another modification. In addition, in response to environmental changes, a dynamic adaptation of the modification status of tRNAs occurs. The present project aims at investigating the relation between tRNA modification circuits and dynamic adaptation of tRNA modifications in response to environmental changes.

Project coordination

Pierre Barraud (Expression génétique microbienne)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


EGM Expression génétique microbienne
LMU Ludwig-Maximilians-Universität München

Help of the ANR 266,726 euros
Beginning and duration of the scientific project: November 2019 - 48 Months

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