ASTRID-Maturation - Accompagnement spécifique des travaux de recherches et d'innovation Défense : Maturation et Valorisation

Immobilization of oligosaccharide scavengers on textiles against neurotoxic organophosphorus agents – TEXT-épur-OP

Submission summary

Organophosphorus nerve agents are irreversible inhibitors of acetylcholinesterase (AChE), a key enzyme in the cholinergic neurotransmission. Chemical warfare agents and the most powerful pesticides belong to this family of compounds. In the case of dissemination of organophosphate nerve agents in the atmosphere, the most urgent is to protect civilian and military people, and relief staff. For this purpose, a decontamination is needed. Time remains a key factor against an attack using chemical weapons. However, despite the recent progress of the chemical defense, it has shortcomings: in the case of a such attack, the current means are not sufficient. Our strategy is then to develop chemical scavengers in order to trap and to hydrolyze organophosphates before they reach their biological targets. These scavengers would be used as decontaminants against chemical warfare agents. This proposal is focused on the development of functionalized textiles by oligosaccharide structures. Further investigations have to be implemented in this field. This work will be performed from a scavenger that previously showed a promising OPasique activity against G agents. Various methods of immobilization on textile will be tested, in order to reinforce the strength of the linker between the textile and the scavengers molecules by modifying the oligosaccharidic structure, and to keep a decontamination efficiency closed to that obtained with the scavenger during in vitro tests in solution. The aim is to gradually transfer the technology to a business partner of the project specialized in textile finishing. At the end of this project, evolution through a prototype in an operational environment will be considered. This kind of fabric could be used to design decontamination wipes or decontamination sponges against chemical warfare agents. Market opportunities are twofold: the military through the DGA and the Civil Defense. The aim of the project is to obtain a more targeted "C" (chemical) protection, the implementation of such products would thus extend protection "C" to larger populations (civil or military) who could so far not have access to such devices. At this stage, the use of the final object on flexible or rigid surface is only considered (on outfits, on various materials and in the local environment). The use of this device on the skin will need further studies including parameters to human health. Studies conducted through this project will tend to take in account data allowing the determination of the duration of activity of the functionalized textile, its storage conditions, and its optimal operating conditions.

Project coordination

François ESTOUR (Chimie Organique Bioorganique Réactivité et Analyse)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

MDB TEXINOV
DE L' HABILLEMENT INSTITUT FRANCAIS DU TEXTILE ET
COBRA (UMR 6014 CNRS) Chimie Organique Bioorganique Réactivité et Analyse

Help of the ANR 483,612 euros
Beginning and duration of the scientific project: February 2015 - 36 Months

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