CE07 - Chimie moléculaire

Hydroamination of unactivated alkenes with NH3 induced by high frequency ultrasound – AminoSound

Submission summary

The aim of this research project is to evaluate the potential of the high frequency ultrasound technology in strategic and industrially relevant reactions for which technological breakthroughs are expected. In particular, and on the basis of preliminary results we collected, we propose to study the contribution of high frequency ultrasound for the activation of ammonia with the ultimate objective of carrying out hydroamination reactions of unactivated olefins (mainly linear olefins) with NH3. This is a timely research project since its addresses a long standing synthetic challenges in hydroamination chemistry and other difficult reactions not realized by using chemical catalysis approach. Although hydroamination of unactivated olefins with NH3 are appealing in principle, it is very challenging in practice and it is a scarcely explored reaction because of thermodynamic limitations and difficulties in activating NH3. Unactivated alkenes mentioned in this project refer to cheap and abundant linear alkenes whose C=C bond is not activated by a functional group or by geometric constraints.

Summarily, the overall hypotheses of this project “AminoSound” will be concentrated on the (i) use cavitation bubbles as micro-reactor for the activation of N-H bonds in NH3 for the generation of NH2 radicals, (ii) in-situ trapping of the amino radicals with the olefin (substrates) for hydroamination reactions, and (iii) use of pressure locally released on liquid during the collapse of cavitation bubbles to thermodynamically promote the hydroamination reaction.

Project coordinator

Monsieur Prince AMANIAMPONG (Institut de Chimie des Milieux et Matériaux de Poitiers)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

IC2MP Institut de Chimie des Milieux et Matériaux de Poitiers

Help of the ANR 213,840 euros
Beginning and duration of the scientific project: October 2020 - 36 Months

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