CE17 - Recherche translationnelle en santé

Pathophysiological mechanisms of subthalamic nucleus deep brain stimulation in obsessive compulsive disorder – NEUROCD

Submission summary

Some severe forms of obsessive-compulsive disorder (OCD) may benefit from deep brain stimulation (DBS) of the subthalamic nucleus. So far, the number of OCD patients treated with this innovative therapy remains limited, and although strict inclusion criteria have been defined based primarily on lesion surgery criteria (e.g. clinical severity, co-morbidity and treatment resistance), the clinical outcome varies from excellent to poor between patients for reasons that are still unclear.
The long-term objective of NEUROCD is to provide new biomarkers measured during motivational processes impacted by OCD to better predict and optimize the efficacy of DBS for OCD.
To do so, we will use an original combination of approaches from the fields of cognitive neuroscience, computational psychiatry and electrophysiology. We will first delineate the most relevant dimensions of decision-making impairments that correlate with OCD severity by using a computational phenotyping approach based on a battery of behavioral tests. We will next identify the cortico-subcortical brain activities underlying the most striking decision-making deficits and confront these neural activities to the clinical outcome of DBS. We will finally quantify the effects of DBS in OCD on brain and behavior on the largest population of operated patients existing worldwide to our knowledge. Based on these measures, we will eventually define the best responder profile to STN DBS, thus improving the selection process for this therapeutical strategy.
Altogether, NEUROCD is expected to provide novel insights in OCD pathophysiology by better delineating the cortico-subcortical brain activity associated with key decision-making processes impaired in OCD and at the clinical level, NEUROCD will provide feedbacks to psychiatrists by developing a network neuroscience approach of deep brain stimulation to unlock the full potential of this innovative therapy.

Project coordination

Mircea POLOSAN (GRENOBLE INSTITUT DES NEUROSCIENCES)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

INM Institut de Neuromodulation
GIN GRENOBLE INSTITUT DES NEUROSCIENCES

Help of the ANR 577,319 euros
Beginning and duration of the scientific project: March 2024 - 48 Months

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