Synthesis of degradable particles by free radical polymerization in dispersed – CKAPART
Therefore, there is an unmet fundamental and industrial need for new synthetic strategies to develop degradable polyester-like particles that could circumvent the limitations of current systems in terms of process and colloidal features and advantageously replace some specific traditional latexes to yield more eco-friendly materials.
Polyesters- or in-chain ester-containing vinyl polymers can indeed be obtained via a free radical (co)polymerization of cyclic ketene acetal (CKA), a class of monomers able to undergo radical ring opening (co)polymerization (rRO(co)P). The radical nature of rROP opens the way to its transposition in dispersed media, the preferred industrial process to produce high solids content vinyl polymer particle dispersion, particularly in water. This is however associated with real challenges related to hydrolytic stability of CKAs.
The aim of the CKAPART project is to develop innovative strategies to prepare degradable vinyl copolymers in dispersed media by producing polyester-like particles. To meet this challenge, a range of new CKAs being hydrophilic, hydrophobic or functional will be synthesized and evaluated in miniemulsion or seeded emulsion polymerizations. CKAPART further wants to assess the degradability and the potential of the obtained particles dispersed in water for the formation of nanocarriers for drug delivery and imaging applications.
Monsieur Franck D'Agosto (CHIMIE, CATALYSE, POLYMERES ET PROCEDES)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
C2P2 CHIMIE, CATALYSE, POLYMERES ET PROCEDES
ICR Institut de Chimie Radicalaire
IGPS Institut Galien Paris Sud
Help of the ANR 527,385 euros
Beginning and duration of the scientific project: September 2018 - 42 Months