One of the most enigmatic host-pathogen system concerns directly transmissible cancers, in which the pathogen is a clonal infectious malignant cell line. By an integration of molecular, ecological and evolutionary approaches, including modelling, the project TRANSCAN proposes to decipher the biology of 2 emblematic transmissible cancers: the Tasmanian devil (Sarcophilus harrisii) and their two facial tumors and the recently discovered horizontally transmitted leukemia in mussels (Mytilus spp). TRANSCAN is organized around 4 questions: 1) why do transmissible cancers emerge ? 2) How do they evolve? 3) what are their ecological and evolution impacts ? and 4) How to manage them ? Not only TRANSCAN will provide novel and unprecedented information on the biology of transmissible cancers it will also provide a conceptual and theoretical framework that explain and predict the evolution of transmissible cancers, and how to prevent victim wildlife populations from potential extinction.
Monsieur Frédéric THOMAS (Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
ISEM Institut des Sciences de l'Evolution de Montpellier
IHPE Interactions Hôtes-Pathogènes-Environnements
UMMISCO Benjamin Roche
MIVEGEC Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle
Help of the ANR 526,133 euros
Beginning and duration of the scientific project: October 2018 - 48 Months