DS03 - Stimuler le renouveau industriel

Cavity-separated Lewis Pairs, a new platform for cooperative activation in the catalytic conversion of small molecules – CaSPair

Submission summary

Inspired by Frustrated Lewis Pairs and cooperative catalysis, the CasPair project will study new catalysts in which the inclusion of a Lewis partner inside a cavity controls frustration of a Lewis pair to form an unexplored Cavity-Separated Lewis Pair (SLP). The congestion of the reactive center inside a cavity opens new venues by ensuring separation of the Lewis pair while maintaining a controlled access to the active sites, providing a long range separation to avoid poisoning by the reagents or products, controlling the approach of the substrates to the reactive centers to favor chemo- and regio-selectivities.

The CaSPair project aims at synthesizing the first SLPs, based on cyclodextrin scaffolds, and at using them as ligands in transition metal-based catalysts or as metal-free systems for the activation and catalytic conversion of small molecules such as CO2 and H2, whose activation is challenging, as they are non-polar and feature strong bonds.

Project coordination

Matthieu Sollogoub (Institut Parisien de Chimie Moléculaire)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


Institut Rayonnement et Matière de Saclay
IPCM Institut Parisien de Chimie Moléculaire

Help of the ANR 389,586 euros
Beginning and duration of the scientific project: January 2018 - 48 Months

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