CE09 - Nanomatériaux et nanotechnologies pour les produits du futur

Lanthanide-Loaded Polymer Nanoparticles for Autofluorescence-Free In Vitro and In Vivo Biosensing and Imaging – LaPin

Submission summary

Sensitivity and selectivity of luminescence techniques for sensing and imaging depend on signal-to-background ratios and thus on the applied probes. In this project, we will design lanthanide (Ln) based nanoprobes that combine high brightness (high signal) with autofluorescence-free (low background) detection. Three types of Ln complexes, for time-gating, upconversion, and short-wavelength infrared (SWIR) detection, will be encapsulated in novel polymer nanoparticles. Optimizing their loading and luminescence properties require a precise control over the encapsulation of the complexes inside the NPs and thus matching complex, polymer, and assembly conditions. The resulting nanoprobes will be biofunctionalized to (i) enable luminescence imaging at the single-particle level in complex biological systems, (ii) implement strongly reduced detection limits and high selectivity for biomarkers without sample-purification, and (iii) provide exceptional resolution for in vivo imaging.

Project coordination

Andreas REISCH (Laboratoire de Bioimagerie et Pathologies (UMR 7021))

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


LBP_UNISTRA Laboratoire de Bioimagerie et Pathologies (UMR 7021)
IAB Institut pour l'Avancée des Biosciences
IPHC Institut Pluridisciplinaire Hubert Curien - IPHC (UMR 7178)

Help of the ANR 572,083 euros
Beginning and duration of the scientific project: - 42 Months

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