Blanc SVSE 5 - Blanc - SVSE 5 - Physique, chimie du vivant et innovations biotechnologiques

In vivo mechanics during tissue morphogenesis – MorFor

How subcellular forces shape tissues

Probing and manipulating supramolecular assemblies which control cell shape changes in tissues

Probing subcellular forces in vivo

We aim at developing, adapting and applying a set of methods to measure mechanical forces in vivo.

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ongoing project

Tissue engineering and understanding of the mechanics during tissue morphogenesis

ongoing

Mechanical forces are as important as genes and chemical signals for the control of embryological development, morphogenesis and tissue patterning. However, we still lack quantitative approaches to study the mechanics of cells and tissues in vivo and the mechanisms of force generation are still poorly understood. In this context, our project aims at developing, adapting and applying a set of physical methods to measure the fields of forces and deformations and determine the viscoelastic properties of a tissue in vivo over different lengthscales (subcellular, cellular and muticellular). Using this approach, we will explore the patterning of cell shape oscillations and the coupling between contractile events in a coherent sheet of cells (epithelial layer of early Drosophila embryo), which represent widespread, yet not well understood mechanisms for tissue morphogenesis. We will also investigate the potential role of calcium in triggering/controlling contractile events. We expect that our findings will have implications in basic biological sciences but also in tissue engineering.

Project coordinator

Monsieur Pierre-François Lenne (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - DELEGATION REGIONALE PROVENCE CORSE) – pierre-francois.lenne@univ-amu.fr

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

CNRS DR 12 _ IBDML CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - DELEGATION REGIONALE PROVENCE CORSE

Help of the ANR 430,000 euros
Beginning and duration of the scientific project: - 48 Months

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