CE19 - Technologies pour la santé

Tools for Tb RadioIsotope Production for nuclear medicine – TTRIP

Submission summary

Novel radio-isotopes are important in nuclear medicine to increase possibilities of imaging/therapies, and to better personalize treatments to the different patients. Their development is strongly constrained by the possibility of producing them in sufficient quantity with high chemical and isotopic purity. TTRIP will take the opportunity of an efficient isotope separator for the production of very pure stable Gd-155 as precursor of Tb-155, which in turn is used for SPECT imaging as one of the Tb quadruplet theranostic isotopes. Characterization of this precursor and its irradiation to produce Tb-155 will complete this proof-of-concept experiment. Parametric studies will then be done to find optimal conditions of this whole process of production. In parallel, a bifunctional chelator will be designed and bioconjugated to monoclonal antibodies and nanobodies. The sought bioconjugates should be able to withstand mild 155Tb labeling conditions to avoid the denaturation of the biological vector.

Project coordination

Charles-Olivier Bacri (Laboratoire de physique des 2 infinis – Irène Joliot-Curie)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

SUBATECH LABORATOIRE DE PHYSIQUE SUBATOMIQUE ET DES TECHNOLOGIES ASSOCIEES
ICMUB INSTITUT DE CHIMIE MOLECULAIRE DE L'UNIVERSITE DE BOURGOGNE - UMR 6302
IC-UNISTRA Institut de Chimie de Strasbourg (UMR 7177)
GANIL Grand accélérateur national d'ions lourds
IJCLab Laboratoire de physique des 2 infinis – Irène Joliot-Curie

Help of the ANR 465,222 euros
Beginning and duration of the scientific project: December 2021 - 48 Months

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