CE17 - Recherche translationnelle en santé

Evaluation of photobiomodulation potential to slow down Huntington's disease – Light4HD

Submission summary

Photobiomodulation, or light therapy, slow down the neurodegenerative process in models of Parkinson's disease. Other studies illustrate that light limit some symptoms of Alzheimer's disease. Huntington's disease is a neurodegenerative disease without any treatment, and presenting several similarities with Parkinson's and Alzheimer's diseases. We would like to assess if photobiomodulation has a therapeutic potential to slow down Huntington's disease. For this we plan a study on a mouse model of Huntington's disease: the animals will be illuminated , early in the disease progression; at the end of the study, we will compare the motor and cognitive symptoms of control (untreated) and light-treated mice, and will evaluate by histology whether the light has allowed neuroprotection.

Project coordinator

Madame Cécile Moro (Laboratoire d'Electronique et de Technologie de l'Information)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

LETI Laboratoire d'Electronique et de Technologie de l'Information

Help of the ANR 224,231 euros
Beginning and duration of the scientific project: February 2023 - 36 Months

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