CE04 - Innovations scientifiques et technologiques pour accompagner la transition écologique

A novel sensing method for the detection of pharmaceuticals in water – DETECMED

DETECMED

A novel sensing method for the detection of pharmaceuticals in water

Monitoring of micropollutants in water

Micropollutants, among them pharmaceuticals, represent an alarming concern for water quality due to their toxicity, persistence, and low removal rate by conventional water treatments. The EU parliament pointed to the need for innovative solutions for treatment but also control of those emerging pollutants for which high quality monitoring data are particularly lacking. Here, we propose to develop a sensing method for the specific, rapid and sensitive detection of molecules in water.

Our solution, based on our single-DNA tethered particle mobility sensor in combination with recognition elements, involves cutting-edge techniques and know how in bionanotechnology, chemistry and immunodetection.
DETECMED is particularly interested in the detection and quantification of drug residues. It targets the detection of three substances of interest diclofenac, an analgesic, ciprofloxacin, an antibiotic, and carbamazepine, an anticonvulsant.

The project is underway. Two of the candidate molecules were modified to insert them into the DNA molecules of the biochip and to use them in the selection process of recognition elements (nanobodies). Preliminary measurements made it possible to demonstrate the feasibility of detection by the competition tests envisaged.

Focused on three particularly relevant substances, our project aims at developing a generic solution for the detection of a large panel of molecules and will pave the way towards a versatile platform for the cost-effective monitoring of surface waters.

International Conference
Digital sensing of substances in water using a single-DNA biochip L. Salomé, D. Soukarié, C. Tardin, V. Ecochard, S. Serres, J-M Escudier, 3rd International Conference on Analytical and Bioanalytical Methods, Virtual meeting, Octobre 2021

Conferences in France
Détection sensible et rapide de substances dans l’eau basée sur une biopuce à molécules d’ADN uniques. L. Salomé, D. Soukarié, C. Tardin, V. Ecochard, S. Serres, J-M Escudier, 14e congrès international du GRUTTEE, Toulouse, Mars 2022
Détection sensible et rapide de contaminants dans l’eau à l’aide d’une biopuce à molécules d’ADN uniques. L. Salomé. Journée Club AFSEP-Sud Ouest, Toulouse, Mars 2022

Micropollutants, among them pharmaceuticals, represent an alarming concern for water quality due to their toxicity, persistence, and low removal rate by conventional water treatments. The EU parliament pointed to the need for innovative solutions for treatment but also control of those emerging pollutants for which high quality monitoring data are particularly lacking. Here, we propose to develop a sensing method for the specific, rapid and sensitive detection of molecules in water. Our solution, based on our single-DNA tethered particle mobility sensor in combination with engineered recognition elements, involves cutting-edge techniques and know how in bionanotechnology, chemistry and immunodetection. Focused on three particularly relevant substances diclofenac, ciprofloxacin and carbamazepine our project aims at developing a generic solution for the detection of a large panel of molecules and will pave the way towards a versatile platform for the cost-effective monitoring of surface waters.

Project coordination

Laurence SALOME (INSTITUT de PHARMACOLOGIE et de BIOLOGIE STRUCTURALE)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

SPCMIB SYNTHESE ET PHYSICOCHIMIE DE MOLECULES D'INTERET BIOLOGIQUE
IPBS INSTITUT de PHARMACOLOGIE et de BIOLOGIE STRUCTURALE
DETROI Diabète-athérothrombose Thérapies Réunion Océan Indien

Help of the ANR 557,226 euros
Beginning and duration of the scientific project: March 2021 - 42 Months

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