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Structural, mechanistic and inhibitor design studies of the Bunya- and Arenavirus L-proteins – ArenaBunya-L
Arenaviridae, Bunyaviridae and Orthomyxoviridae are segmented negative strand single-stranded RNA viruses and include many serious and/or emerging human pathogens (e.g. Lassa Fever, Crimean-Congo Hemorrhagic Fever and Influenza viruses). For arena- and bunyaviruses, transcription and replication of the viral genome segments is performed by the single chain RNA-dependent RNA polymerase (RdRP) or L-protein, which is functionally similar to the hetero-trimeric influenza polymerase complex.
Multi-functional memory elements using supramolecular self constructing interconnects – MultiSelf
The self-assembly of supramolecular architectures is used for realizing organic conductors with metallic properties, allowing us to test the possibility of transferring the spin information of the charge carriers, which can be modified through the electric, magnetic , or electromagnetic field. Novel devices can thus be realized.
Chemistry with quantum Monte Carlo – QMC=Chem
The aim of the QMC=Chem project is to develop an original simulation method allowing to use the computer as a virtual chemistry laboratory. This is made possible thanks to the overwhelming performance of supercomputers.
Kinetically-tunable self-immolative aromatic spacers – KITUSE
After a photoactivation step, one or more bioactive compounds or fluorescent reporters will be released through the use of a self-immolative spacer.
MRAM (Magnetic Memory) based Architecture for Reliable and low power Systems – MARS
the advent of memory technologies combining new features (non-volatility, density, performance, low power
Architecture for MObiquitous REsilient Systems – AMORES
data that we coin as locanyms. To offer such features, the geo-primitives require some basic components
Interaction PGL /lectins and modulation of the host immune response by mycobacterial pathogens – PGLECT
We aim to follow complementary approaches in chemistry, microbiology, cell biology and immunology to unravel the molecular mechanisms of the immunomodulation of host cell response by bacterial lipids specific from the tuberculosis, leprosy or Buruli ulcer bacilli.
Use of Non-Innocent Ligands complexes as VERSatile ALternatives to noble metals – UNILVERSAL
In a context of increasingly compelling environmental and sustainability issues, this project is seeking to develop cost-effective alternatives to the use of noble metals in catalytic processes.
Non-Linear waves and turbulence in stratified and rotating fluids – ONLITUR
Non-linear waves and turbulence in rotating and stratified flows