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Inhibition of coronaviruses infections using innovative nanostructures – NanoMERS
The main goal of the NanoMERS project is the identification of specific and efficient nanomaterials derived anti-MERS-CoV agents effectively inhibiting viral entry and their in vitro and in vivo testing. The focusis on the use of carbon based nanostructures, notably modified C-dots and graphene-dots and nanoparticle formulations of poly(D, L-lactide-co-glycolide) (PLGA).
Sustainable intensification of fruit production systems through innovative pest biological control technologies – Pest free fruit
In sub-Saharan Africa, fruit production is affected by pests that strongly impact on attaining food and nutrition security. The excessive reliance on chemicals is not sustainable, and current pest control methods are insufficient to minimize crop losses. Innovations relying on ecologically-based control become crucial to respond efficiently to sustainable fruit production, as well as societal concerns for safer and nutritionally-balanced diets, better health and environmental protection.
New diagnostic and therapeutic solutions to cotrol bleeding complications during the use of mechanical circulatory support devices
WITECMO a commencé en janvier 2018. L'épidémie de coronavirus a ralenti les inclusions en 2020 et 2021, mais
Rabies virus RNA capping machinery as antiviral target – RAB-CAP
for positive strand RNA viruses (Dengue & Coronaviruses). Although these positive strand RNA viruses
Identification of novel inhibitors against emerging human coronaviruses SARS-CoV and MERS-CoV from host cellular transcriptionic signatures – CoV-SigN
In 2012, a novel human coronavirus (MERS-CoV) was identified in the Middle East as the causative agent [...] and community clusters. Emergence of this new coronavirus in humans raises concerns about a possible widespread [...] required to fight against these emerging hazardous coronaviruses adequately. In this context, the main objective
Ecoepidemiology of coronaviruses, from wildlife to the human population, and assessment of the emerging potential – EPICOREM
environmental changes. Among RNA viruses, coronaviruses (CoVs) are unique in that, on the one hand, [...] will prove attractive to French experts on coronaviruses, and other experts in wildlife, and enable complex
SARS RNA Synthesis and Processing Activities – SARS-RNA-SPA
We deciphered regulation mechanisms of the polymerase activity in the replication / transcription complex and we have identified a proofreading mechanism unique in RNA virus world. In addition, we characterize the viral enzymes involved in the synthesis of the cap structure present at the 5 ' end of mRNA. This structure is needed to translate RNA into viral proteins and limit their recognition by innate immunity mechanisms.
Immunostimulating molecules with a broad-spectrum antiviral activity: a proof of concept in non-human primate models – STING-2.0
measles virus, human parainfluenza virus 3, coronavirus 229E) for which there is no treatment available
Tax reforms and tax revolts in democracies – TAXREV
Questions linked to the design and implementation of redistributive tax policies have occupied a growing position on the public agenda over recent years. Moreover, the fiscal pressures brought upon by the current coronavirus crisis will ensure that these issues maintain considerable political significance for years to come.
Multi-omic analysis of anti-viral immunity: From the identification of relevant biological pathways to the discovery of inborn errors of immunity – GENVIR
pandemics of influenza viruses, Ebola virus, and coronaviruses with the current dramatic example of SARS-CoV-2