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Study of immune crosstalk in COVID-19 – COVIMUNE
Coronavirus disease 2019 (COVID-19) is caused by «severe acute respiratory syndrome coronavirus 2« (SARS-CoV-2). First identified in 2019 in Wuhan, China, it has since spread globally, resulting in the pandemic. While the majority of cases result in mild symptoms, some progress to severe pneumonia a
Lung cell senescence as a target to combat COVID-19 – SENOCOVID
The new coronavirus disease 2019 (COVID-19) due to infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) constitutes a major socio-economic and health burden. Understanding the biological mechanisms underlying the greater susceptibility of the elderly and of those with comorbidit
Pathological findings in critically-ill patients who died from SARS-CoV-2 related acute respiratory distress syndrome – HISTOCOVID
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARScov2) is a new coronavirus discovered in December 2019 in Wuhan, China and currently responsible of a worldwide outbreak and the death of more than 25,000 patients in France. The more severe form of COVID-19 disease induces a pneumonia with pr
Development of SARS-CoV-2 vaccines – DC-CoVaC
Résumé: SARS-CoV-2 is a betacoronavirus that has recently emerged as a human pathogen in the city of Wuhan in China’s Hubei province. The disease caused by this newly identified virus has been named COVID-19 and symptoms include fever, severe respiratory illness and pneumonia. As of March 2020, the
Seroprevalence of IgG antibodies to SARS-CoV-2 in primary health care workers and their household contacts. – COVID-SeroPRIM
Current knowledge regarding the level of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is mainly based on mathematical modeling, and most reports describing the prevalence of the infection are focused on inpatients and/or hospital health care workers (HCWs). However, to our k
Inborn errors of immunity underlying life-threatening COVID-19 in previously healthy patients – GENCOVID
The major role of human genetic variability in immunity to infection is now well established, in particular for viral infections. We have identified a number of monogenic inborn errors of immunity (IEIs) underlying life-threatening viral diseases, such as herpes simplex virus encephalitis, fulminant
Trust in science and public institutions challenged by Covid-19 – CIESCO
How can we find the right words and arguments to convince the population to adopt behaviors that are healthful, not on an individual basis but in the name of the general interest? The CIESCO project aims to understand the conditions of reception and acceptance of speeches made by government offici
Identification of early biomarkers of the response to corticosteroid therapy in COVID-19 patients. – CortiCoV
SARS-CoV-2 is the human coronavirus that caused the pandemic that began in Wuhan, China at the end of 2019. This virus is the source of a contagious respiratory pathology known as COVID-19. The study of the first patients infected with severe forms of COVID-19 revealed an intense inflammatory respon
Comprehension of MAIT cell functions during COVID-19 – COMAIT-19
Dysregulated host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the lung can lead to life-threatening acute respiratory distress syndrome (ARDS). The molecular and cellular host factors implicated in this uncontrolled inflammatory response recently emerged. Howev
The role of the Army in the "war" against the coronavirus and its perception by the population – ARMY
This proposal aims at questioning the mobilization of the military in the fight against the coronavirus, designated as an "invisible enemy". The objective of the project is twofold. On the one hand, it analyzes the decision-making process within the political institutions of the State and the Army
