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Identifying SARS-CoV-2-like and other coronaviruses able to infect humans in bats from Indochina peninsula
objective of the project is to identify bat coronaviruses close to SARS-CoV-2 and other alpha and bet
LabCom PHYTOMAR’INNOV
polyphenols for the prevention of coronavirus infection. The coronaviruses responsible for three epidemics
Autoantibodies against type I IFNs in Lebanese patients hospitalized with COVID-19.
Since 2003, three coronaviruses, SARS, MERS, and SARS-CoV-2, have led to devastating pandemics. Although [...] vaccines are available, new variants and even new coronaviruses could emerge at any time. Understanding the
Engineering nanobinders to block SARS-CoV-2 entry
The novel coronavirus SARS-CoV-2 has recently emerged as a human pathogen in China’s Hubei province, [...] high-titer neutralizing antibodies in others coronaviruses and to fold independently from other spike domains
NSP3 polyprotein of SARS-CoV2: structural studies and its exploration in drug screening campaign
alarming emerging infectious disease caused by coronavirus (CoV). The current COVID-19 pandemic, which [...] Wuhan region of China, is caused by a novel coronavirus, SARS-CoV2 which is more infectious than the
Identification of SARS-CoV-2 RNA ibinding proteins durig viral replication
caused by a novel coronavirus (CoV), the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Inhibition of coronaviruses infections using innovative nanostructures
The main goal of the NanoMERS project is the identification of specific and efficient nanomaterials derived anti-MERS-CoV agents effectively inhibiting viral entry and their in vitro and in vivo testing. The focusis on the use of carbon based nanostructures, notably modified C-dots and graphene-dots and nanoparticle formulations of poly(D, L-lactide-co-glycolide) (PLGA).
Identification of novel inhibitors against emerging human coronaviruses SARS-CoV and MERS-CoV from host cellular transcriptionic signatures
In 2012, a novel human coronavirus (MERS-CoV) was identified in the Middle East as the causative agent [...] and community clusters. Emergence of this new coronavirus in humans raises concerns about a possible widespread [...] required to fight against these emerging hazardous coronaviruses adequately. In this context, the main objective
Study of immune crosstalk in COVID-19
We hypothesize that antigen presenting cells determine, based on human leucocyte antigens (HLAs) and viral antigens to activate T cell response, whether infection leads to disease pathogenesis or a protective immune response resulting in milder disease and/or long-term protection to SARS-CoV-2.
Inborn errors of immunity underlying life-threatening COVID-19 in previously healthy patients
In December 2019, a pneumonia due to a novel coronavirus (SARS-CoV-2) emerged in the city of Wuhan, China [...] ranging from asymptomatic infection to lethal coronavirus infectious disease-19 (COVID-19). Two groups
