Call for Proposals for Transnational Research Projects on Mechanisms of Resilience and Vulnerability to Environmental Challenges in Mental Health - ERA-NET NEURON COFUND 2 - 2023

The aim of the call is to facilitate multinational, collaborative research projects that will address critical translational questions to improve our knowledge concerning neurobiological mechanisms involved in resilience or vulnerability to environmental challenges in mental health.

The present call aims to fund preclinical research up to proof-of-concept clinical studies  addressing neurobiological mechanistic understanding of vulnerability and resilience to mental disorders. Research areas may cover a broad range of aspects including among others genetic, epigenetic, anatomical, molecular, immunological, and endocrine mechanisms.

Proposals aiming at developing predictive, preventative, diagnostic and/or therapeutic approaches with the potential to enhance resilience based on known or hypothesized neurobiological mechanisms are within the scope of this call, as are proposals to understand the neurobiological basis of therapeutic technologies promoting resilience.

Research proposals should cover at least one of the following areas:

• Fundamental research addressing mental health vulnerability and resilience including the pathogenesis, aetiology, progression, treatment, and prevention of mental diseases initiated by exposure to adverse environmental challenges. This may include the use of knowledge on neurobiological mechanisms for the development of innovative technologies with the potential to promote mental health, reduce the incidence of mental disorders and improve clinical outcomes.
   
• Clinical research addressing mental health vulnerability and resilience aiming to develop novel strategies for prevention, diagnosis, patient stratification, therapy and/or rehabilitation for mental diseases initiated by exposure to adverse environmental challenges. This may include research proposals aiming at the identification of neurobiological targets to enhance resilience.