LabCom_2022 - V2 - Laboratoires communs organismes de recherche publics – PME/ETI - Edition 2022 - Vague 2

Probiotics and Phytonutrients for the Health of the Gut-Brain Axis – ProPhySICe Lab

Submission summary

The gut-brain axis in Alzheimer's disease. A neurodegenerative disease is a generic term for a heterogeneous group of pathologies affecting various populations of neurons in the central nervous system. These incurable and incapacitating diseases progressively lead to a state of dependence for the people concerned. Among them, Alzheimer's disease is the most common cause of age-related dementia (more than 60% of cases). More than 35 million people worldwide suffer from this disease today and, according to the WHO, this number is expected to double every 20 years. Alzheimer's disease most often manifests after the age of 65 by a progressive loss of memory, the appearance of cognitive and spatio-temporal orientation disorders due to the death of nerve cells and can extend to other behavioral and motor disorders.

The LabCom ProPhySICe Lab which associates the Laboratory of Interactions between Commensal Microorganisms and Probiotics with the Host (ProbiHôte) within the MICALIS Institute (for Food Microbiology for Human Health) (UMR 1319 INRAE-AgroParisTech-Université Paris-Saclay, 78350 Jouy en Josas) and the company PiLeJe, aims to develop new solutions based on phytonutrients and probiotics to intervene on the gut-brain axis, particularly in the case of Alzheimer's patients. The development of these innovative strategies would, in the medium term, improve the quality of life of patients and delay the health consequences of Alzheimer's disease and other neurodegenerative pathologies. These strategies could in the near future represent effective tools of prevention and complementary treatment for these pathologies for which no curative treatment exists until now. Our project aims at creating a common laboratory between the ProbiHôte team and the PiLeJe company with all the expertise and tools to design, build and produce such innovative strategies. The skills of this joint laboratory (ProPhySICe Lab) will allow the development of potential new prevention tools that can be produced as food supplements by PiLeJe and tested in human clinical trials.

Project coordination

Philippe Langella (MICrobiologie de l'ALImentation au service de la Santé)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


MICALIS MICrobiologie de l'ALImentation au service de la Santé
[PILEJE] PiLeJe PiLeJe Laboratoire

Help of the ANR 363,000 euros
Beginning and duration of the scientific project: March 2023 - 54 Months

Useful links

Explorez notre base de projets financés



ANR makes available its datasets on funded projects, click here to find more.

Sign up for the latest news:
Subscribe to our newsletter