ERANET JPcofuND 2 - NM - Appel à projets transnational sur les mécanismes des interventions non médicamenteuses pour les maladies neurodégénératives

Rebalancing sleep-wake disturbances in Parkinson's Disease with deep brain stimulation – RECAST

Submission summary

In this consortium, we wish to address the original mechanistic questions of “where”, “when” and “how” to stimulate the human SN in an aim to modulate circadian rhythms and sleep cycles to improve SWD in PD; more specifically: Can we identify the distinct spatial distribution (“where”) and firing patterns (“how”) of the sleep-related neurons described in the rodent SN also in the human SN with imaging techniques (e.g., neuromelanin-sensitive, susceptibility-weighted and connectivity-based neuroimaging, structure-symptom analysis) and physiological recordings (e.g., multiunit activity and local field potentials, LFP)? Can the timing of SN-DBS (“when”) with regard to the circadian cycle improve daytime arousal and SWD? Do these physiologically informed stimulation paradigms induce plastic changes in sleep-related local circuits and brain networks? Can the difficult sleep stage scoring in PD be performed in an automated and online manner by machine learning approaches to trigger stimulation? Can the classical EEG-based arousal and sleep classification be conducted on the basis of LFP recordings in the STN/SN region via the novel sensing capabilities of the new generation of DBS devices that has recently become available? Can we determine the optimal pattern of SN-DBS (“how”) in relation to the macro- and micro-sleep architecture? Does this physiologically-informed, state-dependent SN-DBS improve sleep dynamics? Do these interventions improve the circadian rhythm and disease progression as captured by clinical und subclinical measures (e.g., perturbations in cellular and molecular sub-networks), and multimodal quantification of structural and functional brain network changes?

Project coordination

Alireza Gharabaghi ()

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

ICM Institut du Cerveau

Help of the ANR 1,420,888 euros
Beginning and duration of the scientific project: June 2023 - 36 Months

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