CE51 - Sciences de l’ingénierie et des procédés

A Millifluidic smart reactor system for multistep continuous synthesis of bio-based styrenes derived from p-hydroxycinnamic acids – MilliStyrene

Submission summary

Over the last twenty years, scientists have become increasingly interested in intensifying the production processes of biomolecules such as plant secondary metabolites. Intensification strategies are mainly focused on engineering microbial strains to produce heterologous plant metabolites. The implementation in microorganisms of plant biosynthetic pathways is a promising strategy to produce high value biomolecules. However, to strengthen the industrial feasibility of these bioprocesses, it appeared necessary to create innovative separation processes. Indeed, it is well known that the global cost of bioprocesses is often largely impacted by the cost of downstream processing.
The MilliStyrene project aims to create a continuous and robust extractive fermentation process potentially associated with the transformation of the recovered biomolecule by chemical or enzymatic or even biological means. The project brings together three research and development teams with complementary expertise in (i) fermentation and chemo-enzymatic conversions, (ii) analysis of molecule transfer in complex media, (iii) modeling and design of prototype tools. The theoretical understanding of the phenomena and the validation of the proof of concept will allow the design of an extractive fermentation pilot system able to replace advantageously current in situ product recovery (ISPR) processes. Thus, the MilliStyrene project is a key step towards the future development of heterologous production processes of plant metabolites fully in line with the concept of environmental, economic and social sustainability.

Project coordination


The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


C.R.P.P Centre national de la recherche scientifique
LGPM CentraleSupélec

Help of the ANR 525,773 euros
Beginning and duration of the scientific project: December 2022 - 48 Months

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