CE45 - Interfaces: mathématiques, sciences du numérique –biologie, santé

Simulation Based Network Structure Inference Constrained by Observed Spike Trains – SIMBADNESTICOST

Submission summary

Neurophysiologists are nowadays able to record from a large number of extracellular electrodes and to extract, from the raw data, the sequences of action potentials or spikes generated by many neurons. Unfortunately these "many neurons" still represent only a tiny fraction of the neuronal population which constitutes the network. Using association statistics such as the estimation of the cross-correlation functions, they try and infer the structure of the network formed by the recorded neurons. But this inference is compromised by the tremendous under-sampling of the neuronal population and by the errors made during the sequences reconstruction. This yields a "network picture" usually called a "functional network" whose features depend strongly on the recording conditions (such as the presence/absence of a stimulation). We consider that reconstructing the network formed by the recorded neurons is an ill-posed problem. We propose to focus instead on the "generative probability distribution" of the network: what is the probability to have a connection from a type A neuron to a type B neuron? Is the probability to have a connection from neuron Y of type B to neuron X of type A dependent on the presence of a connection from X to Y? We propose to simulate first the whole network using a simplified neuronal dynamics and different (parametrized) generative probability distributions. We will then compare the association statistics between the simulated and the experimentally observed cases. This type of approach is now commonly used in several fields under different names like "Approximate Bayesian Computation" or "Simulation based Inference". We will then be able to asses if there is an "over representation of reciprocal connections" using data from the first olfactory relay of an insect.

Project coordination

Christophe Pouzat (Université Strasbourg)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


IRMA Université Strasbourg

Help of the ANR 159,330 euros
Beginning and duration of the scientific project: December 2022 - 48 Months

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