Aid-decision making platform to PREDICT Abdominal aortic aneurysm outcomes – PREDICTA

Cardiovascular diseases are the leading cause of premature death in developed countries. Among them, abdominal aortic aneurysm (AAA) has become a significant health public challenge worldwide, with extremely high rates of mortality in case of rupture. The only curative treatment relies on surgery and clinicians are confronted to a critical lack of tools to evaluate the outcomes of patients. As a result, some patients are treated while they would never have ruptured and others with an AAA below the threshold for treatment do develop a fatal rupture. By bringing a practical solution to tackle the unpredictability of AAA, PREDICTA project will be a major breakthrough for cares provided to patients. The aim is to create an innovative aid-decision platform to predict AAA outcomes to enable precision medicine and develop a personalized therapeutic approach. We propose to take up the challenge to use innovative techniques in biology and imaging to identify new patterns and to combine them using artificial intelligence (AI) to develop efficient predictive models.
The main tools developed in the platform will include: - Automatization of vascular imaging analysis and generation of a novel AI-based tool for pre-surgical planning. – Prediction of AAA progression using Machine Learning by combining clinical, imaging and omics data obtained from patients with AAA. – Prediction of the post-operative outcomes and the risk of endoleaks.
The PREDICTA platform will increment all the applications developed and will provide a decision support system that will be tested in a multicentre study to test and optimize its use for clinical practice.