Molecular mechanisms of heme acquisition by Haemophilus influenzae Hgps – HAPTOHEME
Haemophilus influenzae is a bacterium that causes a range of human infections. Since H. influenzae lacks most enzymes of the heme biosynthetic pathway, it has an absolute growth requirement for protoporphyrin IX, the immediate precursor of heme. H. influenzae is one of the few microorganisms able to scavenge heme from the hemoglobin-haptoglobin complex present in human serum. Haptoglobin is a glycoprotein capturing free hemoglobin released in the serum during hemolysis. By allowing the elimination of this potentially toxic products, haptoglobin prevent oxidative damages to the host. At the same time, it participates in the host defense against infection by restricting certain pathogens access to an essential nutrient. The goal of the HAPTOHEME project is to determine the mechanism by which H. influenzae is able to acquire heme from hemoglobin or the haptoglobin-hemoglobin complex.
Madame Nathalie Dautin (Laboratoire de biologie physico-chimique des protéines membranaires)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
IPL-BSI Insitut Pasteur de Lille - ERL - Biologie structurale intégrative
LBPCPM Laboratoire de biologie physico-chimique des protéines membranaires
Help of the ANR 380,177 euros
Beginning and duration of the scientific project: January 2023 - 48 Months