CE07 - Chimie moléculaire

Lanthanide(III)-based modular metallacrowns for imaging in the NIR-II spectral window – LACRONIR

Submission summary

Optical imaging in the second near-infrared (NIR-II) window (1000-1700 nm) provides additional advantages over imaging in the visible and in the first near-infrared (NIR-I) window by significantly enhancing contrast, temporal and spatial resolution as well as the signal-to-noise ratio. However, today, the limited choice of probes emitting in the NIR-II is the real bottleneck. The main goals of this project are (i) to create a new family of photostable modular lanthanide(III)-based metallacrowns suitable for imaging in the NIR-II window; and (ii) to establish structure - properties relationships in order to rationalize the design of such probes. To demonstrate the potential of the created metallacrowns as probes for optical imaging in the NIR-II window, they will be coupled with specific peptides targeting small-conductance potassium channels (SKCa) and tested in a multiplex optical imaging approach on model cells. Further, the created metallacrowns will be evaluated by NIR-II macroscopy using tissue-mimicking phantoms to estimate their potential for in vivo applications. The obtained results will be a basis for the rational design of NIR-II probes and their translation to preclinical and clinical use.

Project coordination

Svetlana Eliseeva (Centre national de la recherche scientifique)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

ICOA Université Orléans
N2C Université de Tours
University of Michigan, Department of Chemistry
CBM Centre national de la recherche scientifique

Help of the ANR 419,958 euros
Beginning and duration of the scientific project: November 2022 - 48 Months

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