CE07 - Chimie moléculaire

Cyclodextrin-based Molecular Motor – CycloMMotor

Submission summary

The present project aims at the elaboration of novel cyclodextrin-based chemical motors, either rotatory in a [2]catenane or long-range translational in a rotaxane architecture. The originality of the proposed project is to obtain unidirectional motion of the cyclodextrin (CD) on the axle by a mechanism where the CD would open its own way, like a snowplow moves forward on the road by pushing the snow aside. Chemically speaking, the system is composed of an axle with at least two protecting groups constituting cleavable temporary stoppers and an ?-CD, functionalized on the primary rim by a defined number of catalytic functions. The net directionality results from an information ratchet mechanism with two kinetic biases: in the protection step the orientation of the conic shape of the CD favors the reaction next to the large rim, and the second is related to the presence of a catalytic group on the small rim of the CD that should accelerate the deprotection step. Furthermore, by controlling the functionalization of the CD we aim at controlling the speed of motion. In doing so we would go well-beyond the state of the art and propose an original concept in the very challenging field of molecular motors.
The realization of this project would be performed at the Paris Institute of Molecular Chemistry at Sorbonne University, Paris by a team that unites knowledge in CD functionalization, supramolecular chemistry and molecular machines. The outcome of the project would pave the way for the development of complex systems with changes in macroscopic properties or out-of-equilibrium transport, based on controlled motion on the molecular level.

Project coordination

Bernold Hasenknopf (Sorbonne Université)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

IPCM Sorbonne Université

Help of the ANR 259,900 euros
Beginning and duration of the scientific project: January 2023 - 36 Months

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