CE07 - Chimie moléculaire

Towards the Development of New Redox Electro-Catalytic and Asymmetric Processes – ElectroPHOS

Submission summary

Phosphines play a key role as stoichiometric reagents in a variety of impactful transformations daily used in laboratories all over the world. Despite their usefulness, these reactions possess a major drawback, namely the concomitant formation of a stoichiometric quantity of phosphine oxide. This often complicates the purification of large-scale processes, decreases the atom economy of these reactions and makes impossible the development of asymmetric versions of these transformations, due to the prohibitive cost of chiral phosphines. Within the framework of this project we propose to develop electro-catalytic transformations, using a sub-stoichiometric amount of phosphine. Around this central project, we will put complementary experts in their respective scientific fields: (1) phosphorus chemistry and catalysis, (2) electrosynthesis and analytical electrochemistry, and (3) physical organic chemistry to better understand the properties required of phosphines and substrates for the development of such processes. This project could represent an important step forward in the field of organic synthesis and more generally towards the development of more sustainable catalytic and asymmetric processes.

Project coordination

Arnaud VOITURIEZ (Centre national de la recherche scientifique)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

DCM Département de Chimie Moléculaire
ICSN Centre national de la recherche scientifique
LHFA Université Toulouse 3 - Paul Sabatier
LHFA LABORATOIRE HETEROCHIMIE FONDAMENTALE ET APPLIQUEE

Help of the ANR 484,219 euros
Beginning and duration of the scientific project: December 2022 - 48 Months

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