CE07 - Chimie moléculaire

Nickel-catalyzed coupling reactions: A big step towards a more sustainable access to ethers – NiCatEther

Submission summary

Ether compounds are ubiquitous in molecules of interest such as therapeutic agents or agrochemical products for example. Actual classical strategies for their syntheses are mainly based on cross-coupling reactions involving Pd or Cu catalysts in association with aryl halides and phenol derivatives as starting materials. These reagents are either toxic or generate unusable waste. In this project, using nickel as an Earth abundant, non-toxic and cheap metal, we plan to develop two strategies to limit the toxicity of the reagents and wastes. The first one is based on the use of H2O as a unique oxygen atom donor, thus avoiding the use of phenol derivatives. In the second one, ester derivatives will be used as reagents, leading to the expected ethers products thanks to a decarbonylative process, generating CO as only by-product. To succeed, the project will be divided in classical tasks in the field of homogeneous catalysis (ligands and metal complexes design and synthesis, catalysis and mechanistic studies). Based on preliminary results, nickel catalysts with DPPA-type ligands will be developed and used for the targeted reactions. A strong investment will be devoted to mechanistic studies. Indeed, a deep understanding of the mechanism will allow the access to more efficient catalysts and will probably help to envision new synthetic pathways for other cross-coupling reactions. A strong interplay between the LCC and LCM partners who both possess expertise and know-how in the different fields will guaranty the success of the project.

Project coordination

Pascal Guillo (Laboratoire de Chime et de coordination)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

LCM Ecole Polytechnique
LCC Laboratoire de Chime et de coordination

Help of the ANR 443,818 euros
Beginning and duration of the scientific project: September 2022 - 48 Months

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