CE07 - Chimie moléculaire

Experimental & Theoretical Exploration of Unique in & ex situ Generated [n]Cumulenimines in Reaction Cascades – A Structure, Reactivity and Selectivity study – ETE-Cumul

Submission summary

Design & development of innovative step & atom economic syntheses of complex polycyclic molecules – relevant for medicinal, agrochemical or material sciences – is of great challenge for modern organic chemistry. As such, the search for new synthetic methods in organic chemistry should meet society's expectations of environmental benign and energy efficient/saving processes. Strategies involving transition metal catalyzed or metal-free reaction cascades are privileged means to answer these environmental and economic issues. Merging the expertise of researchers in synthetic organic, theoretical and computational chemistry, the multidisciplinary ETE-Cumul project deals with the experimental and theoretical exploration of unprecedented [n]cumulenimines as versatile building blocks for organic synthesis. Highly unsaturated and reactive [n]cumulenimines shall be able to initiate transition metal catalyzed & metal free reaction cascades leading to a variety of heterocycles with potential use in the fields of pharmaceutical, agrochemical and materials research. Taking profit of the complementary expertise of the involved partners, the full chain of knowledge from in situ, ex situ and in silico synthesis & molecular structure characterization, novel methodology in synthesis, chemical reactivity, as wells as a detailed understanding of reaction mechanism and reaction development will be covered. Such a systematic study of the chemistry and reactivity profile of new [n]cumulenimines will be highly beneficial for chemistry research regarding target and/or diversity-oriented synthesis, new reaction cascades, new molecule synthesis and asymmetric transformations.

Project coordination

Bernhard Witulski (Laboratoire de Chimie Moléculaire et Thio-organique)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

ICBMS INSTITUT DE CHIMIE ET BIOCHIMIE MOLECULAIRES ET SUPRAMOLECULAIRES
LCMT Laboratoire de Chimie Moléculaire et Thio-organique

Help of the ANR 361,939 euros
Beginning and duration of the scientific project: January 2023 - 42 Months

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