Résilience - COVID-19 - Résilience - Coronavirus disease 2019

Immune characterization after plasma exchange treatment during severe COVID-19 infection – CovidEP-Immuno

Submission summary

During COVID-19 pandemia, the EFS contributes to the global effort of research to better understand this disease and to treat the most severe patients while decreasing the incidence and tension in hospitalisations. The CovidEP study (authorized by ANSM and CPP – HCL sponsor / Scientific coordination EFS Auvergne-Rhône-Alpes Dr O Hequet) pursues to remove cytokines in excess that induce inappropriate immune responses in patients in intensive care unit and to study the immune improvements. The aim of this study is to clarify whether this aproach leads to restore an appropriate and efficient immune response while overcoming a critical medical position in severe patients infected with COVID-19.
In practice, this is performed by removing plasma (containing cytokines in excess) from patients with COVID-19 and replacing it by fresh frozen plasma form healthy donors during therapeutic plasma exchange sessions (TPE). The analysis of immune responses, mainly T lymphocyte immune responses and platelet activation after cytokine removing, will be compared to the reponses in patients without TPE. Currently the immune features are not evaluated during TPE for COVID-19. The current support concerns the physiopathological analysis of the complications observed in patients in intensive care unit and the immnological improvments induced by this TPE approach, while concentrating on inflammation, T lymphocyte immune response and platelet activation.

Project coordination

Olivier Héquet (EFS Auvergne-Rhône-Alpes)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

SAINBIOSE SAnté INgenierie BIOlogie Saint-Etienne - U1059
EFS AuRA EFS Auvergne-Rhône-Alpes
EFS AuRA EFS Auvergne-Rhône-Alpes

Help of the ANR 79,487 euros
Beginning and duration of the scientific project: May 2021 - 12 Months

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