CE35 - Maladies infectieuses et environnement

Coinfection and the evolution of strategies of within-host persistence – COINFECT

Submission summary

Hosts are usually infected by multiple parasites simultaneously. These parasites can be in conflict or benefit from the presence of each other. In this project, we wish to investigate the consequences of the infection by an intestinal nematode with immunosuppressive effects, on the infection dynamics of a Plasmodium species, both parasites infecting house mice. In the first work package, we wish to run a series of experiments to investigate the role of order and timing of infection on the infection dynamics and the cost paid by the host. In the second work package, we will implement an experimental evolution approach where the two parasites will be allowed to evolve under single infection conditions or under co-infection. In the third work package, we will adopt a modelling approach to investigate more broadly the conditions promoting the evolution of immunosuppressive strategies and the consequences on the co-infection dynamics.

Project coordination

Gabriele Sorci (BIOGEOSCIENCES - UMR 6282)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

MIVEGEC Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle
LNC LIPIDES NUTRITION CANCER - INSERM U866
BGS BIOGEOSCIENCES - UMR 6282

Help of the ANR 557,287 euros
Beginning and duration of the scientific project: January 2022 - 48 Months

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