CE35 - Maladies infectieuses et environnement

Role of protein intrinsic disorder in potyvirus adaptation to its host – ID4VISA21

Submission summary

Plant health is of paramount importance to ensure food supplies for a growing world population. The Potyvirus genus is the most damaging group to crops. The high mutational frequency of these viruses results in an adaptive potential compromising the sustainability of host resistance. Understanding the molecular basis of their adaptation is of prime importance to derive sustainable resistance strategies. Many biologically active proteins possess intrinsically disordered regions (IDRs), e.g. regions devoid of stable structure and yet exerting biological function(s). Given the strong evolutionary potential of potyviruses on the one hand, and the high IDR content in their proteome on the other, this project aims at assessing the contribution of intrinsic disorder to the mechanisms of adaptation to the host.

Project coordination

Thierry Michon (Biologie du Fruit et Pathologie)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

BFP Biologie du Fruit et Pathologie
INRAE PACA - PV Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement - Centre de Recherche INRAE PACA - Pathologie Végétale

Help of the ANR 451,819 euros
Beginning and duration of the scientific project: December 2021 - 48 Months

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